Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Cowin, Gary J., Jonsson, Julie R., Bauer, Judith D., Ash, Susan, Ali, Azmat, Osland, Emma J., Purdie, David M., Clouston, Andrew D., Powell, Elizabeth E. and Galloway, Graham J. (2008) Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. Journal of Magnetic Resonance Imaging, 28 4: 937-945. doi:10.1002/jmri.21542

Author Cowin, Gary J.
Jonsson, Julie R.
Bauer, Judith D.
Ash, Susan
Ali, Azmat
Osland, Emma J.
Purdie, David M.
Clouston, Andrew D.
Powell, Elizabeth E.
Galloway, Graham J.
Title Magnetic resonance imaging and spectroscopy for monitoring liver steatosis
Journal name Journal of Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 1053-1807
Publication date 2008
Year available 2008
Sub-type Article (original research)
DOI 10.1002/jmri.21542
Volume 28
Issue 4
Start page 937
End page 945
Total pages 9
Editor C. L. Partain
Place of publication New York, United States America
Publisher Wiley-Liss
Collection year 2009
Language eng
Subject 110320 Radiology and Organ Imaging
920203 Diagnostic Methods
110307 Gastroenterology and Hepatology
Formatted abstract
To compare noninvasive MRI and magnetic resonance spectroscopy (MRS) methods with liver biopsy to quantify liver fat content.

Materials and Methods
Quantification of liver fat was compared by liver biopsy, proton MRS, and MRI using in-phase/out-of-phase (IP/OP) and plus/minus fat saturation (±FS) techniques. The reproducibility of each MR measure was also determined. An additional group of overweight patients with steatosis underwent hepatic MRI and MRS before and after a six-month weight-loss program.

A close correlation was demonstrated between histological assessment of steatosis and measurement of intrahepatocellular lipid (IHCL) by MRS (rs = 0.928, P < 0.0001) and MRI (IP/OP rs = 0.942, P < 0.0001; FS rs = 0.935, P < 0.0001). Following weight reduction, four of five patients with >5% weight loss had a decrease in IHCL of 50%.


These findings suggest that standard MRI protocols provide a rapid, safe, and quantitative assessment of hepatic steatosis. This is important because MRS is not available on all clinical MRI systems. This will enable noninvasive monitoring of the effects of interventions such as weight loss or pharmacotherapy in patients with fatty liver diseases.
Keyword Liver fat
Weight loss
Insulin resistance
Fatty liver disease
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
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Created: Wed, 18 Mar 2009, 17:10:14 EST by Lesley-Jayne Jerrard on behalf of Centre For Magnetic Resonance