Bacterial mechanosensitive channels: Experiment and theory

Corry, B. and Martinac, B. (2008) Bacterial mechanosensitive channels: Experiment and theory. Biochimica Et Biophysica Acta-Biomembranes, 1778 9: 1859-1870. doi:10.1016/j.bbamem.2007.06.022

Author Corry, B.
Martinac, B.
Title Bacterial mechanosensitive channels: Experiment and theory
Journal name Biochimica Et Biophysica Acta-Biomembranes   Check publisher's open access policy
ISSN 0005-2736
Publication date 2008
Year available 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbamem.2007.06.022
Open Access Status
Volume 1778
Issue 9
Start page 1859
End page 1870
Total pages 12
Editor Yeagle, P. L.
Epand, R. M.
Place of publication Netherlands
Publisher Elsevier
Collection year 2009
Language dut
Subject 060110 Receptors and Membrane Biology
920108 Immune System and Allergy
Abstract Since their discovery in Escherichia coli some 20 years ago, studies of bacterial mechanosensitive (MS) ion channels have been at the forefront of the MS channel research field. Two major events greatly advanced the research on bacterial MS channels: (i) cloning of MscL and MscS, the MS channels of Large and Small conductance, and (ii) solving their 3D crystal structure. These events enabled further experimental studies employing EPR and FRET spectroscopy in addition to patch clamp and molecular biological techniques that have successfully been used in characterization of the structure and function of bacterial NIS channels. In parallel with the experimental studies computational modelling has been applied to elucidate the molecular dynamics of MscL and MscS, which has significantly contributed to our understanding of basic physical principles of the mechanosensory transduction in living organisms.
Keyword MS channels
patch clamp
bilayer model
mechanosensory transduction
EPR spectroscopy
molecular dynamics
Brownian dynamics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Available online 6 July 2007, in print September 2008

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 18 Mar 2009, 12:09:10 EST