Bacterial mechanosensitive channels: Experiment and theory

Corry, B. and Martinac, B. (2008) Bacterial mechanosensitive channels: Experiment and theory. Biochimica Et Biophysica Acta-Biomembranes, 1778 9: 1859-1870.


Author Corry, B.
Martinac, B.
Title Bacterial mechanosensitive channels: Experiment and theory
Journal name Biochimica Et Biophysica Acta-Biomembranes   Check publisher's open access policy
ISSN 0005-2736
Publication date 2008
Year available 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbamem.2007.06.022
Volume 1778
Issue 9
Start page 1859
End page 1870
Total pages 12
Editor Yeagle, PL
Epand, RM
Place of publication Netherlands
Publisher Elsevier BV
Collection year 2009
Language dut
Subject C1

060110 Receptors and Membrane Biology
920108 Immune System and Allergy
Abstract Since their discovery in Escherichia coli some 20 years ago, studies of bacterial mechanosensitive (MS) ion channels have been at the forefront of the MS channel research field. Two major events greatly advanced the research on bacterial MS channels: (i) cloning of MscL and MscS, the MS channels of Large and Small conductance, and (ii) solving their 3D crystal structure. These events enabled further experimental studies employing EPR and FRET spectroscopy in addition to patch clamp and molecular biological techniques that have successfully been used in characterization of the structure and function of bacterial NIS channels. In parallel with the experimental studies computational modelling has been applied to elucidate the molecular dynamics of MscL and MscS, which has significantly contributed to our understanding of basic physical principles of the mechanosensory transduction in living organisms. (C) 2007 Elsevier B.V. All rights reserved.
Keyword MS channels
patch clamp
bilayer model
mechanosensory transduction
EPR spectroscopy
FRET
molecular dynamics
Brownian dynamics
MOLECULAR-DYNAMICS SIMULATIONS
SMALL-CONDUCTANCE MSCS
ESCHERICHIA-COLI MSCS
ION-CHANNEL
GATING MECHANISM
PATCH-CLAMP
FUNCTIONAL RECONSTITUTION
BROWNIAN DYNAMICS
MYCOBACTERIUM-TUBERCULOSIS
ACETYLCHOLINE-RECEPTOR
Q-Index Code C1
Additional Notes Available online 6 July 2007, in print September 2008

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Access Statistics: 43 Abstract Views  -  Detailed Statistics
Created: Wed, 18 Mar 2009, 12:09:10 EST