Hematological Malignancies

Wood, P. and Fong, K. M. (2006). Hematological Malignancies. In Geoffrey J. Laurent and Steven D. Shapiro (Ed.), Encyclopedia of Respiratory Medicine (pp. 339-344) New York: Academic Press (Elsevier). doi:10.1016/B0-12-370879-6/00410-5


Author Wood, P.
Fong, K. M.
Title of chapter Hematological Malignancies
Title of book Encyclopedia of Respiratory Medicine
Place of Publication New York
Publisher Academic Press (Elsevier)
Publication Year 2006
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1016/B0-12-370879-6/00410-5
Year available 2006
ISBN 0124383602
978-0124383609
Editor Geoffrey J. Laurent
Steven D. Shapiro
Start page 339
End page 344
Total pages 6
Language eng
Subjects 110203 Respiratory Diseases
Abstract/Summary Most hematological malignancies involving the thorax are lymphomas either Hodgkin or non-Hodgkin in type. These usually present with mediastinal masses in patients in their third and fourth decade, and often reach large size before clinically detectable. Despite that they are often associated with a reasonable prognosis. Other hematological causes are much less common causes of thoracic disease and will be covered in this article. The disorders have been split into extrathoracic and thoracic malignancies. Multiple myeloma is the most common disorder in this group. It has an incidence of 5 per 100000 population for Caucasians. It frequently presents with bone pain (often axial skeleton, clavicles, and ribs), hypercalcemia, and renal impairment. Its recognition is important for appropriate management to minimize complications and symptoms. Treatment usually consists of chemotherapy and/or radiotherapy. Newer immunomodulatory therapies will be discussed. Stem cell transplantation is appropriate for a minority of patients. Cutaneous malignancy may be evident on thoracic examination and should be considered in the workup. Finally, patients may present with hemorrhagic complications of hematological malignancy. Although these disorders are rare, they are easily excluded by careful laboratory and clinical evaluation.
Keyword Myeloma
Chloroma
Granulocytic sarcoma
Leukemia cutis
Coagulopathy
Thalidomide
Bortezomib
Lenalidomide
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Available online 02 May 2006. Published as a four volume set: Volumes 1-4.

 
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Created: Tue, 17 Mar 2009, 13:16:38 EST by Mary-Anne Marrington on behalf of School of Medicine