Association of arsenic and kidney dysfunction in people with diabetes and validation of its effects in rats

Wang, J. P., Wang, S. L., Lin, Q., Zhang, L., Huang, D. and Ng, J. C. (2009) Association of arsenic and kidney dysfunction in people with diabetes and validation of its effects in rats. Environment International, 35 3: 507-511.


Author Wang, J. P.
Wang, S. L.
Lin, Q.
Zhang, L.
Huang, D.
Ng, J. C.
Title Association of arsenic and kidney dysfunction in people with diabetes and validation of its effects in rats
Journal name Environment International  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2009
Sub-type Article
Year available 2008
DOI 10.1016/j.envint.2008.07.015
Volume number 35
Issue number 3
ISSN 0160-4120
Start page 507
End page 511
Total pages 5
Editor R. E. Alcock
Place of publication Amsterdam
Publisher Elsevier Science Ltd (Pergamon)
Collection year 2009
Language eng
Subject C1
111506 Toxicology (incl.Clinical Toxicology)
111705 Environmental and Occupational Health and Safety
920405 Environmental Health
920104 Diabetes
Abstract We studied villagers with and without diabetes from arsenic-endemic areas and a nearby control site in Xinjiang Autonomous Region, PR China. Water and urinary arsenic were assayed for exposure measurement. Urinary NAG (N-acetyl-β-glucosaminidase), a kidney function test, blood glucose, triglyceride, cholesterol, high density lipid and low density lipid were measured. Villagers from endemic areas were found to have higher urinary arsenic concentrations. The NAG results also suggest that chronic arsenic exposure presents a significant adverse impact on the kidney function of villagers in the endemic areas. However, blood glucose levels of diabetes individuals were lower than those from the control site. These observations were validated in rats which were chronically exposed to arsenic in drinking water. The distinct relationship between chronic arsenic exposure and diabetes mellitus requires further investigation. A rodent model is a useful tool for study of this type.
Keyword Arsenic
Diabetes
Kidney dysfunction
NAG
N-acetyl-β-glucosaminidase
China
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Available online 14 September 2008 Crown copyright © 2008

 
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Created: Sat, 14 Mar 2009, 08:15:20 EST by Marie-Louise Moore on behalf of National Res Centre For Environmental Toxicology