Arsenicosis status and urinary malondialdehyde (MDA) in people exposed to arsenic contaminated-coal in China

Wang, Jian Ping, Maddalena, Robyn, Zheng, Baoshan, Zai, Chen, Liu, Faye and Ng, Jack C. (2009) Arsenicosis status and urinary malondialdehyde (MDA) in people exposed to arsenic contaminated-coal in China. Environment International, 35 3: 502-506. doi:10.1016/j.envint.2008.07.016

Author Wang, Jian Ping
Maddalena, Robyn
Zheng, Baoshan
Zai, Chen
Liu, Faye
Ng, Jack C.
Title Arsenicosis status and urinary malondialdehyde (MDA) in people exposed to arsenic contaminated-coal in China
Journal name Environment International   Check publisher's open access policy
ISSN 0160-4120
Publication date 2009-04
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.envint.2008.07.016
Volume 35
Issue 3
Start page 502
End page 506
Total pages 5
Editor R. E. Alcock
Place of publication United Kingdom
Publisher Elsevier Science Ltd (Pergamon)
Collection year 2009
Language eng
Subject C1
111506 Toxicology (incl.Clinical Toxicology)
111705 Environmental and Occupational Health and Safety
920405 Environmental Health
Abstract The current arsenic exposure condition, arsenicosis prevalence, urinary arsenic and MDA (malondialdehyde) concentrations in people were studied. The study area, a village in Xing Ren County in Guizhou Province, PR China, is a coal-borne arsenicosis endemic area that was identified several decades ago. The residents in Xing Ren have been using coal containing high arsenic levels all their life. Urinary arsenic levels of villagers were 192.2 ± 22 µg/g creatinine (n = 113) in the coal-borne endemic area (Xing Ren county) and were significantly higher than 63.6 ± 5.9 µg/g creatinine (n = 30) in a neighbouring control site (a village in Xing Yi county). The urinary MDA concentrations of villagers from the endemic area were also significantly higher compared to those of the control area. There was a strong correlation between age and urinary arsenic and MDA concentrations in the endemic area of Xing Ren; urinary arsenic and MDA levels decreased with age. Fifty out of 113 (44.3%) villagers in the endemic area had arsenicosis symptoms and the prevalence in villagers older than 40 y was 100% in male (92.2% overall). Urinary MDA concentration was significantly higher in people with arsenicosis symptoms in the endemic areas. Oxidative stress (urinary MDA concentration) was strongly related to arsenic exposure but not to the age and smoking habit. Higher urinary arsenic and MDA levels in younger villagers from the endemic area suggest that they are having a higher exposure to coal-borne emitted arsenic because they spend more time indoor. There is an urgent need to develop proper intervention methods in the Guizhou endemic areas in order to reduce the risk to the local communities who are still using arsenic contaminated-coal.
Keyword Arsenic
Oxidative stress
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Available online 11 September 2008 Crown copyright © 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
National Research Centre for Environmental Toxicology Publications
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Created: Sat, 14 Mar 2009, 08:11:44 EST by Marie-Louise Moore on behalf of National Res Centre For Environmental Toxicology