Altered white matter diffusion anisotropy in normal and preterm infants at term equivalent age

Rose, Stephen E., Hatzigeorgiou, Xanthy, Strudwick, Mark W., Durbridge, Gail L., Davies, Peter S. W. and Colditz, Paul B. (2008) Altered white matter diffusion anisotropy in normal and preterm infants at term equivalent age. Magnetic Resonance in Medicine, 60 4: 761-767. doi:10.1002/mrm.21689


Author Rose, Stephen E.
Hatzigeorgiou, Xanthy
Strudwick, Mark W.
Durbridge, Gail L.
Davies, Peter S. W.
Colditz, Paul B.
Title Altered white matter diffusion anisotropy in normal and preterm infants at term equivalent age
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
Publication date 2008
Sub-type Article (original research)
DOI 10.1002/mrm.21689
Volume 60
Issue 4
Start page 761
End page 767
Total pages 7
Editor F. W. Wehrli
Place of publication USA
Publisher Wiley Interscience
Collection year 2009
Language eng
Subject 110320 Radiology and Organ Imaging
920203 Diagnostic Methods
C1
Abstract To investigate white matter (WM) development, voxelwise analyses of diffusion tensor MRI (DTMRI) data, acquired from 12 very preterm and 11 preterm infants with gestational ages (GA) ranging from 25 to 29 and 29 to 32 weeks, respectively, and 10 newborn normal term infants were performed. T2 relaxation measures were also generated to assess brain water content. Compared with newborn term infants, very preterm infants were found to possess reduced fractional anisotropy (FA) within the frontal lobe, and a number of anterior and posterior commissural pathways. Preterm infants possessed reduced FA mainly within the posterior regions of the corpus callosum. Unexpectedly, we observed significantly reduced FA and increased T2 within a number of corticospinal projections in the newborn term infants compared to the preterm groups. This finding may reflect increased water concentration and/or a lowering of FA due to the presence of crossing interhemispheric WM projections. These findings indicate that care should be taken when interpreting FA indices without knowledge of the possible effects of water concentration in the newborn infant brain. Magn Reson Med 60:761-767, 2008. © 2008 Wiley-Liss, Inc.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Thu, 12 Mar 2009, 17:02:14 EST by Lesley-Jayne Jerrard on behalf of Centre For Magnetic Resonance