Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

Faber, Elizabeth S. L., Delaney, Andrew J., Power, John M., Sedlak, Petra, Crane, James W. and Sah, Pankaj (2008) Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala. Journal of Neuroscience, 28 43: 10803-10813. doi:10.1523/JNEUROSCI.1796-08.2008

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Author Faber, Elizabeth S. L.
Delaney, Andrew J.
Power, John M.
Sedlak, Petra
Crane, James W.
Sah, Pankaj
Title Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 2070-6474
1529-2401
Publication date 2008-10-22
Year available 2008
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.1796-08.2008
Open Access Status File (Publisher version)
Volume 28
Issue 43
Start page 10803
End page 10813
Total pages 11
Editor John H. R. Maunsell
Place of publication New York, United States
Publisher Society for Neuroscience
Collection year 2009
Language eng
Subject C1
110902 Cellular Nervous System
920111 Nervous System and Disorders
Abstract Emotionally arousing events are particularly well remembered. This effect is known to result from the release of stress hormones and activation of beta adrenoceptors in the amygdala. However, the underlying cellular mechanisms are not understood. Small conductance calcium-activated potassium (SK) channels are present at glutamatergic synapses where they limit synaptic transmission and plasticity. Here, we show that beta adrenoceptor activation regulates synaptic SK channels in lateral amygdala pyramidal neurons, through activation of protein kinase A. We show that SK channels are constitutively recycled from the postsynaptic membrane and that activation of beta adrenoceptors removes SK channels from excitatory synapses. This results in enhanced synaptic transmission and plasticity. Our findings demonstrate a novel mechanism by which beta adrenoceptors control synaptic transmission and plasticity, through regulation of SK channel trafficking, and suggest that modulation of synaptic SK channels may contribute to beta adrenoceptor-mediated potentiation of emotional memories.
Keyword fluorescence microscopy
noradrenergic
norepinephrine
learning and memory
potassium channels
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 51 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 12 Mar 2009, 14:28:40 EST by Debra McMurtrie on behalf of Queensland Brain Institute