A comparison of treatment outcome between adenocarcinoma and squamous cell carcinoma of the eosophagus

Lim, K. H., Thomas, J., Brown, W. A., Harvey, J., Burmeister, B., Walpole, E., Thomson, D., Martin, I., Gotley, D. C. and Smithers, B. M. (2003). A comparison of treatment outcome between adenocarcinoma and squamous cell carcinoma of the eosophagus. In: ANZ Journal of Surgery. -, -, (A63-A63). -.


Author Lim, K. H.
Thomas, J.
Brown, W. A.
Harvey, J.
Burmeister, B.
Walpole, E.
Thomson, D.
Martin, I.
Gotley, D. C.
Smithers, B. M.
Title of paper A comparison of treatment outcome between adenocarcinoma and squamous cell carcinoma of the eosophagus
Conference name -
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Proceedings title ANZ Journal of Surgery   Check publisher's open access policy
Place of Publication Carlton, Victoria
Publisher Blackwell Publishing
Publication Year 2003
DOI 10.1111/j.1445-2197.2003.00009.x
ISSN 1445-1433
1445-2197
0004-8682
Volume 73
Issue s1
Start page A63
End page A63
Total pages 1
Language eng
Abstract/Summary Purpose Combined modality therapy has been used to treat oesophageal cancer. We compared the treatment outcome between adenocarcinoma and squamous cell carcinoma (SCC) in terms of survival and recurrence. Methodology A prospective database of patients with oesophageal cancer was collected from 1988 to 2001. 294 patients with adenocarcinoma and 191 patients with SCC were treated with curative intention. The options included surgical resection alone, neoadjuvant chemoradiotherapy (CRT) (cisplatin 80 mg/m2, 5 fluorouracil 800 mg/m2 and 35 Gy) followed by surgical resection, and definitive CRT (2 courses of cisplatin 80 mg/m2 and 5 fluorouracil 800 mg/m2 and 60 Gy). Kaplan-Meier estimates of survival and the log rank test were used to compare results. Results The survival rate of patients with adenocarcinoma or SCC treated by resection was not significantly different (P = 0.352). Patients with SCC receiving neoadjuvant CRT have a better 2-year survival rate (69.2%) than patients with adenocarcinoma (35.6%)(P = 0.009). Patients with SCC who were treated by definitive CRT also have a better 2-year survival rate (42.4%) than those with adenocarcinoma (26.2%) (P = 0.024). Patients with adenocarcinoma treated with neoadjuvant or definitive CRT have a higher recurrence rate than those with SCC. Distant metastases was the major failure in both histologic groups. Conclusion The results of surgical resection of SCC and adenocarcinoma of the oesophagus were comparable. However, when CRT was included in the treatment either as preoperative or definitive therapy, the outcome was significantly different. Future trials that involve CRT should consider the different histologic types separately.
Subjects 1112 Oncology and Carcinogenesis
110323 Surgery
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Tue, 10 Mar 2009, 16:46:59 EST by Ms Sarada Rao on behalf of Surgery - Princess Alexandra Hospital