Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume

Sran, Meena M., Khan, Karim M., Keiver, Kathy, Chew, Jason B., McKay, Heather A. and Oxland, Thomas R. (2005) Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume. European Spine Journal, 14 10: 971-976.


Author Sran, Meena M.
Khan, Karim M.
Keiver, Kathy
Chew, Jason B.
McKay, Heather A.
Oxland, Thomas R.
Title Accuracy of DXA scanning of the thoracic spine: cadaveric studies comparing BMC, areal BMD and geometric estimates of volumetric BMD against ash weight and CT measures of bone volume
Journal name European Spine Journal   Check publisher's open access policy
ISSN 0940-6719
1432-0932
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1007/s00586-004-0836-8
Volume 14
Issue 10
Start page 971
End page 976
Total pages 6
Place of publication Wien, Austria
Publisher Springer
Language eng
Subject 1103 Clinical Sciences
Abstract Biomechanical studies of the thoracic spine often scan cadaveric segments by dual energy X-ray absorptiometry (DXA) to obtain measures of bone mass. Only one study has reported the accuracy of lateral scans of thoracic vertebral bodies. The accuracy of DXA scans of thoracic spine segments and of anterior-posterior (AP) thoracic scans has not been investigated. We have examined the accuracy of AP and lateral thoracic DXA scans by comparison with ash weight, the gold-standard for measuring bone mineral content (BMC). We have also compared three methods of estimating volumetric bone mineral density (vBMD) with a novel standard–ash weight (g)/bone volume (cm3) as measured by computed tomography (CT). Twelve T5–T8 spine segments were scanned with DXA (AP and lateral) and CT. The T6 vertebrae were excised, the posterior elements removed and then the vertebral bodies were ashed in a muffle furnace. We proposed a new method of estimating vBMD and compared it with two previously published methods. BMC values from lateral DXA scans displayed the strongest correlation with ash weight (r=0.99) and were on average 12.8% higher (p<0.001). As expected, BMC (AP or lateral) was more strongly correlated with ash weight than areal bone mineral density (aBMD; AP: r=0.54, or lateral: r=0.71) or estimated vBMD. Estimates of vBMD with either of the three methods were strongly and similarly correlated with volumetric BMD calculated by dividing ash weight by CT-derived volume. These data suggest that readily available DXA scanning is an appropriate surrogate measure for thoracic spine bone mineral and that the lateral scan might be the scan method of choice.
Keyword DXA
Accuracy
Thoracic spine
Ash weight
Bone volume
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement Studies Publications
 
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