Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study

Liu, D., Manske, S. L., Kontulainen, S. A., Tang, C., Guy, P., Oxland, T. R. and McKay, H. A. (2007) Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study. Osteoporosis international, 18 7: 991-997. doi:10.1007/s00198-007-0325-0

Author Liu, D.
Manske, S. L.
Kontulainen, S. A.
Tang, C.
Guy, P.
Oxland, T. R.
McKay, H. A.
Title Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study
Journal name Osteoporosis international   Check publisher's open access policy
ISSN 0937-941X
Publication date 2007-07
Sub-type Article (original research)
DOI 10.1007/s00198-007-0325-0
Volume 18
Issue 7
Start page 991
End page 997
Total pages 7
Place of publication London, U. K.
Publisher Springer International
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Summary We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were significantly associated with bone’s mechanical properties. However, cortical density assessed by pQCT was not associated with mechanical properties.
Introduction The primary objective of this study was to determine the contribution of cross-sectional geometry (by MRI and pQCT) and density (by pQCT and DXA) to mechanical properties of the human cadaveric tibia.
Methods We assessed 20 human cadaveric tibiae. Bone cross-sectional geometry variables (total area, cortical area, and section modulus) were measured with MRI and pQCT. Cortical density and areal BMD were measured with pQCT and DXA, respectively. The specimens were tested to failure in a four-point bending apparatus. Coefficients of determination between imaging variables of interest and mechanical properties were determined.
Results Cross-sectional geometry measurements from MRI and pQCT were strongly correlated with bone mechanical properties (r2 range from 0.55 to 0.85). Bone cross-sectional geometry measured by MRI explained a proportion of variance in mechanical properties similar to that explained by pQCT bone cross-sectional geometry measurements and DXA measurements.
Conclusions We found that there was a close association between geometry and mechanical properties regardless of the imaging modality (MRI or pQCT) used.

Keyword Bone strength
Magnetic resonance imaging
Peripheral quantitative computed tomography
Tibia diaphysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 43 times in Thomson Reuters Web of Science Article | Citations
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