Application of magnetic resonance imaging to evaluation of femoral neck structure in growing girls

McKay, Heather A., Sievanen, Harri, Petit, Moira A., MacKelvie, Kerry J., Forkheim, Ken M., Whittall, Ken P., Forster, Bruce B., Macdonald, Heather and Khan, K. M. (2004) Application of magnetic resonance imaging to evaluation of femoral neck structure in growing girls. Journal of Clinical Densitometry, 7 2: 161-168. doi:10.1385/JCD:7:2:161

Author McKay, Heather A.
Sievanen, Harri
Petit, Moira A.
MacKelvie, Kerry J.
Forkheim, Ken M.
Whittall, Ken P.
Forster, Bruce B.
Macdonald, Heather
Khan, K. M.
Title Application of magnetic resonance imaging to evaluation of femoral neck structure in growing girls
Journal name Journal of Clinical Densitometry   Check publisher's open access policy
ISSN 1094-6950
Publication date 2004
Sub-type Article (original research)
DOI 10.1385/JCD:7:2:161
Volume 7
Issue 2
Start page 161
End page 168
Total pages 8
Place of publication Amsterdam
Publisher Elsevier Inc.
Language eng
Subject 1103 Clinical Sciences
Abstract Conventional density measures by dual-energy X-ray absorptiometry (DXA) are confounded by increases in bone size and do not assess bone geometry. We assessed precision of magnetic resonance imaging (MRI) and used MRI, DXA, and hip structure analysis (HSA) to assess 7-mo changes in bone structure at the femoral neck in 18 prepubertal girls. At baseline, girls were 10.4 (0.5) yr, 144.0 (8.2) cm, and 35.2 (7.0) kg, on average. Total bone and cortical cross-sectional area (ToA and CoA) were calculated from high-resolution T1-weighted MRI oblique axial images of the femoral neck. We used proximal femur DXA scans (Hologic QDR-4500) and the HSA program to estimate bone cross-sectional area (CSA), and calculate section modulus. MRI precision was determined by scanning 10 volunteers (13–46 yr old) three times with and without repositioning. Precision (CVrms) was 2% for ToA and 7% for CoA. Significant correlations were observed between FN area and MRI-derived ToA (r = 0.57, p = 0.013) and CoA (r = 0.47, p = 0.050). There were significant positive changes over 7 mo by both methods. In conclusion, MRI provides useful information on femoral neck bone area in children. The reproducibility of cortical dimensions at the femoral neck needs improvement through technical modifications and appropriate analysis software.
Keyword bone
magnetic resonance imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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