Analysing cortical bone cross-sectional geometry by peripheral QCT: Comparison with bone histomorphometry

Kontulainen, S., Liu, D., Manske, S., Jamieson, M., Sievanen, H. and McKay, H. A. (2007) Analysing cortical bone cross-sectional geometry by peripheral QCT: Comparison with bone histomorphometry. Journal of Clinical Densitometry, 10 1: 86-92. doi:10.1016/j.jocd.2006.07.007


Author Kontulainen, S.
Liu, D.
Manske, S.
Jamieson, M.
Sievanen, H.
McKay, H. A.
Title Analysing cortical bone cross-sectional geometry by peripheral QCT: Comparison with bone histomorphometry
Journal name Journal of Clinical Densitometry   Check publisher's open access policy
ISSN 1094-6950
1559-0747
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.jocd.2006.07.007
Volume 10
Issue 1
Start page 86
End page 92
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 1103 Clinical Sciences
Abstract A distinct advantage of peripheral quantitative computed tomography (pQCT) is its ability to assess bone strength by measuring cross-sectional geometry and density of cortical bone. For accurate determination of cortical bone cross-sectional area (CoA), it is important to select the appropriate analysis mode and thresholds. No study has assessed which analysis protocol best represents tibial bone geometry—as determined by histomorphometry. We measured bone geometry from 16 human cadaver tibiae (mean age 74 [SD 6] yr) with pQCT (XCT 2000) at the 25% site, measured proximally from the distal tibia plafond. We conducted histomorphometry at the same site as the criterion standard. Scans were analyzed using modes and thresholds recommended by the manufacturer (Norland Stratec Medizintechnic GmbH, Pforzheim, Germany). We also investigated agreement of two additional thresholds (calculated by half-maximum height and inflection point methods) to define the endosteal border of cortical bone. Compared to the criterion, the smallest error (−1.0%, p = 0.002) in total cross-sectional area (ToA) was obtained using Contour mode 3 with an outer threshold of 169 mg/cm3. The smallest error (0.1%, NS) in CoA was obtained with Separation mode 4 (outer threshold 200 mg/cm3, inner threshold 670 mg/cm3). CoA was overestimated by 5–7% (p < 0.001) from the criterion when an inner threshold of 480 mg/cm3 was used in combination with any of the recommended outer thresholds. pQCT measurements of bone geometry in vitro vary to some extent between modes and thresholds selected. The effect of variation in bone geometry measurements on the predictive ability of bone strength indices derived from CoA needs to be assessed.
Keyword pQCT
Histomorphometry
Bone geometry
Cortical bone area
Accuracy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Human Movement and Nutrition Sciences Publications
 
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