A comparison of published criteria for assuming attainment of adult height in girls who have received growth hormone treatment

Dodrill, P. M., Atkin, L. M. and Davies, P. S. W. (2008) A comparison of published criteria for assuming attainment of adult height in girls who have received growth hormone treatment. Journal of Pediatric Endocrinology & Metabolism, 21 5: 433-437.


Author Dodrill, P. M.
Atkin, L. M.
Davies, P. S. W.
Title A comparison of published criteria for assuming attainment of adult height in girls who have received growth hormone treatment
Journal name Journal of Pediatric Endocrinology & Metabolism   Check publisher's open access policy
ISSN 0334-018X
Publication date 2008-05
Sub-type Article (original research)
Volume 21
Issue 5
Start page 433
End page 437
Total pages 5
Place of publication London, U.K.
Publisher Freund Publishing House
Language eng
Subject C1
110306 Endocrinology
920106 Endocrine Organs and Diseases (excl. Diabetes)
11 Medical and Health Sciences
1114 Paediatrics and Reproductive Medicine
111403 Paediatrics
Formatted abstract  At least six different criteria to assume attainment of adult height in girls who have received growth hormone (GH) treatment have been published in the literature. The aim of this study was to assess whether, if applied to the same population, different criteria for assuming adult height would produce the same outcome. 
METHODS: Data on Australian and New Zealand girls receiving growth hormone (GH) treatment were accessed from the nationwide OZGROW database. Girls were included in the analysis if standing height measurements were available up until the time point when bone age (BA) > or =15 yr and height velocity (HV) < or = 1 cm/yr (n = 684). Participants' height measurements were extracted from the database at the first time point that would be considered to meet the requirements of each criterion. 
RESULTS: ANOVA found no statistically significant differences between the value for girls' adult height assumed when using the various criteria. However, as expected, the greatest (and, thus, most accurate) estimate for adult height was obtained using the most stringent criterion, BA >15 yr and HV <1 cm/yr. The values assumed using the other adult height criteria underestimated this height value by an average of 2.4 cm. 
CONCLUSION: Statistically similar values for adult height in girls who have received GH treatment are obtained using any of the published criteria for assuming adult height that were evaluated. However, in cases where girls who have received GH treatment cannot be followed until the time point when BA > or =15 yr and HV < or = 1 cm/yr, it has to be acknowledged that the assumed adult height is likely to be less than the girl's actual adult height.
Keyword Adult Height
Girls
Growth hormone
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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