Microarray Analysis of Differentially Expressed Genes of Primary Tumors in the Canine Central Nervous System

Thomson, S. A. M., Kennerly, E., Olby, N., Mickelson, J. R., Hoffmann, D. E., Dickinson, P. J., Gibson G. C and Breen, M. (2005) Microarray Analysis of Differentially Expressed Genes of Primary Tumors in the Canine Central Nervous System. Veterinary Pathology, 42 5: 550-558. doi:10.1354/vp.42-5-550


Author Thomson, S. A. M.
Kennerly, E.
Olby, N.
Mickelson, J. R.
Hoffmann, D. E.
Dickinson, P. J.
Gibson G. C
Breen, M.
Title Microarray Analysis of Differentially Expressed Genes of Primary Tumors in the Canine Central Nervous System
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
Publication date 2005
Sub-type Article (original research)
DOI 10.1354/vp.42-5-550
Open Access Status Not Open Access
Volume 42
Issue 5
Start page 550
End page 558
Total pages 9
Place of publication Lawrence, Kansas
Publisher American College of Veterinary Pathologists
Language eng
Subject 0707 Veterinary Sciences
Abstract The pathophysiologic similarities of many human and canine cancers support the role of the domestic dog as a model for brain tumor research. Here we report the construction of a custom canine brain-specific cDNA microarray and the analysis of gene expression patterns of several different types of canine brain tumor. The microarray contained 4000 clones from a canine brain specific cDNA library including 2161 clones that matched known genes or expressed sequence tags (ESTs) and 25 cancer-related genes. Our study included 16 brain tumors (seven meningiomas, five glial tumors, two ependymomas, and two choroid plexus papillomas) from a variety of different dog breeds. We identified several genes previously found to be differentially expressed in human brain tumors. This suggests that human and canine brain tumors share a common pathogenesis. In addition, we also found differentially expressed genes unique to either meningiomas or the glial tumors. This report represents the first global gene expression analysis of different types of canine brain tumors by cDNA microarrays and might aid in the identification of potential candidate genes involved in tumor formation and progression.
Keyword Cdna Microarray
canine choroid plexus tumor
ependymoma;
glial tumor
meningioma.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Articles in English and German. Official organ of the American College of Veterinary Pathologists.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
 
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