Anomalies in the Expression Profile of Interspecific Hybrids of Drosophila melanogaster and Drosophila simulans

Ranz, José M., Namgyal, Kalsang, Gibson, Greg and Hartl, Daniel L. (2004) Anomalies in the Expression Profile of Interspecific Hybrids of Drosophila melanogaster and Drosophila simulans. Genome Research, 14 3: 373-379.


Author Ranz, José M.
Namgyal, Kalsang
Gibson, Greg
Hartl, Daniel L.
Title Anomalies in the Expression Profile of Interspecific Hybrids of Drosophila melanogaster and Drosophila simulans
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
1549-5469
Publication date 2004-03
Sub-type Article (original research)
DOI 10.1101/gr.2019804
Volume 14
Issue 3
Start page 373
End page 379
Total pages 7
Place of publication Cold Spring Harbor, New York
Publisher Cold Spring Harbor Laboratory Press
Language eng
Subject 0604 Genetics
Abstract When females of Drosophila melanogaster and males of Drosophila simulans are mated, the male progeny are inviable, whereas the female progeny display manifold malformations and are sterile. These abnormalities result from genetic incompatibilities accumulated since the time the lineages of the species diverged, and may have their origin in aberrant gene transcription. Because compensatory changes within species may obscure differences at the regulatory level in conventional comparisons of the expression profile between species, we have compared the gene-expression profile of hybrid females with those of females of the parental species in order to identify regulatory incompatibilities. In the hybrid females, we find abnormal levels of messenger RNA for a large fraction of the Drosophila transcriptome. These include a gross underexpression of genes preferentially expressed in females, accompanying gonadal atrophy. The hybrid females also show significant overexpression of male-biased genes, which we attribute to incompatibilities in the regulatory mechanisms that normally act to control the expression of these genes in females. The net result of the multiple incompatibilities is that the gene-expression profiles of the parental females are more similar to each other than either is to that of the hybrid.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
 
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