Absence of the Transcription Factor Nfib Delays the Formation of the Basilar Pontine and Other Mossy Fiber Nuclei

Kumbasar, Asli, Plachez, Celine, Gronostajski, Richard M. and Richards, Linda J. (2009) Absence of the Transcription Factor Nfib Delays the Formation of the Basilar Pontine and Other Mossy Fiber Nuclei. The Journal of Comparative Neurology, 513 1: 98-112.


Author Kumbasar, Asli
Plachez, Celine
Gronostajski, Richard M.
Richards, Linda J.
Title Absence of the Transcription Factor Nfib Delays the Formation of the Basilar Pontine and Other Mossy Fiber Nuclei
Formatted title Nfib
Journal name The Journal of Comparative Neurology  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2009-03
Sub-type Article
Year available 2008
DOI 10.1002/cne.21943
Volume number 513
Issue number 1
ISSN 0021-9967: 1096-9861
Start page 98
End page 112
Total pages 14
Editor Clifford B. Saper
Place of publication United States
Publisher A John Wiley & Sons, Inc
Collection year 2009
Language eng
Subject C1
110902 Cellular Nervous System
110903 Central Nervous System
920111 Nervous System and Disorders
Formatted abstract Transcription factors of the Nuclear Factor I (Nfi) family are important for the development of specific neuronal and glial populations in the nervous system. One such population, the neurons of the basilar pontine nuclei, expresses high levels of Nfi proteins, and the pontine nuclei are greatly reduced in mice lacking a functional Nfib gene. Pontine neurons, along with other precerebellar neurons that populate the hindbrain, arise from precursors in the lower rhombic lip and migrate anteroventrally to reach their final location. Using immunohistochemistry, we find that NFI-B expression is specific for mossy fiber populations of the precerebellar system. Analysis of the Nfib-/- hindbrain indicates that the development of the basilar pontine nuclei is delayed, with pontine neurons migrating 1-2 days later than in control animals, and that significantly fewer pontine neurons are produced. While the mossy fiber nuclei of the caudal medulla do form, they also exhibit a developmental delay. Nfia and Nfix null mice exhibit no apparent pontine phenotype, implying specificity in the action of NFI family members. Collectively, these data demonstrate that Nfib plays an important role in the generation of precerebellar mossy fiber neurons, and may do so at least in part by regulating neurogenesis. J. Comp. Neurol. 513:98-112, 2009. © 2008 Wiley-Liss, Inc.
Keyword precerebellar
mossy fiber
cell migration
neurogenesis
hindbrain
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Created: Thu, 05 Mar 2009, 16:08:00 EST by Debra McMurtrie on behalf of Queensland Brain Institute