Gene expression divergence and the origin of hybrid dysfunctions

Ortíz-Barrientos, Daniel, Counterman, Brian A. and Noor, Mohamed A. F. (2007) Gene expression divergence and the origin of hybrid dysfunctions. Genetica, 129 1: 71-81. doi:10.1007/s10709-006-0034-1

Author Ortíz-Barrientos, Daniel
Counterman, Brian A.
Noor, Mohamed A. F.
Title Gene expression divergence and the origin of hybrid dysfunctions
Journal name Genetica   Check publisher's open access policy
ISSN 0016-6707
Publication date 2007-01
Sub-type Article (original research)
DOI 10.1007/s10709-006-0034-1
Volume 129
Issue 1
Start page 71
End page 81
Total pages 11
Place of publication Dordrecht, Netherlands
Publisher Springer
Language eng
Subject 0604 Genetics
Formatted abstract
Hybrids between closely related species are often sterile or inviable as a consequence of failed interactions between alleles from the different species. Most genetic studies have focused on localizing the alleles associated with these failed interactions, but the mechanistic/biochemical nature of the failed interactions is poorly understood. This review discusses recent studies that may contribute to our understanding of these failed interactions. We focus on the possible contribution of failures in gene expression as an important contributor to hybrid dysfunctions. Although regulatory pathways that share elements in highly divergent taxa may contribute to hybrid dysfunction, various studies suggest that misexpression may be disproportionately great in regulatory pathways containing rapidly evolving, particularly malebiased, genes. We describe three systems that have been analyzed recently with respect to global patterns of gene expression in hybrids versus pure species, each in Drosophila. These studies reveal that quantitative misexpression of genes is associated with hybrid dysfunction. Misexpression of genes has been documented in sterile hybrids relative to pure species, and variation in upstream factors may sometimes cause the over- or under-expression of genes resulting in hybrid sterility or inviability. Studying patterns of evolution between species in regulatory pathways, such as spermatogenesis, should help in identifying which genes are more likely to be contributors to hybrid dysfunction. Ultimately, we hope more functional genetic studies will complement our understanding of the genetic disruptions leading to hybrid dysfunctions and their role in the origin of species.
Keyword Hybrid sterility
Hybrid inviability
Gene expression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
Ecology Centre Publications
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 39 times in Scopus Article | Citations
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Created: Thu, 05 Mar 2009, 11:10:47 EST by Ms Karen Naughton on behalf of School of Biological Sciences