The quantitative genetics of transcription

Gibson, Greg and Weir, Bruce (2005) The quantitative genetics of transcription. Trends in Genetics, 21 11: 616-623. doi:10.1016/j.tig.2005.08.010


Author Gibson, Greg
Weir, Bruce
Title The quantitative genetics of transcription
Journal name Trends in Genetics   Check publisher's open access policy
ISSN 0168-9525
Publication date 2005
Sub-type Article (original research)
DOI 10.1016/j.tig.2005.08.010
Volume 21
Issue 11
Start page 616
End page 623
Total pages 8
Place of publication Amsterdam
Publisher Elsevier Science
Language eng
Subject 0604 Genetics
Abstract Quantitative geneticists have become interested in the heritability of transcription and detection of expression quantitative trait loci (eQTLs). Linkage mapping methods have identified major-effect eQTLs for some transcripts and have shown that regulatory polymorphisms in cis and in trans affect expression. It is also clear that these mapping strategies have little power to detect polygenic factors, and some new statistical approaches are emerging that paint a more complex picture of transcriptional heritability. Several studies imply pervasive non-additivity of transcription, transgressive segregation and epistasis, and future studies will soon document the extent of genotype–environment interaction and population structure at the transcriptional level. The implications of these findings for genotype–phenotype mapping and modeling the evolution of transcription are discussed
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
 
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Created: Thu, 05 Mar 2009, 10:33:59 EST by Alexandra Cooney on behalf of School of Biological Sciences