Why are dendritic cells important in allergic diseases of the respiratory tract?

Upham, John W. and Stumbles, Philip A. (2003) Why are dendritic cells important in allergic diseases of the respiratory tract?. Pharmacology and Therapeutics, 100 1: 75-87. doi:10.1016/S0163-7258(03)00094-9


Author Upham, John W.
Stumbles, Philip A.
Title Why are dendritic cells important in allergic diseases of the respiratory tract?
Journal name Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0163-7258
1879-016X
Publication date 2003-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0163-7258(03)00094-9
Volume 100
Issue 1
Start page 75
End page 87
Total pages 13
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Subject 110701 Allergy
110203 Respiratory Diseases
Abstract Increasing evidence points to the role of antigen-presenting dendritic cells (DC) in regulating adaptive immune responses. DC are especially sensitive to signals derived from microbes, allergens, and the airway tissue microenvironment, can polarize naı¨ve T-cells into either Th1 or Th2 effector cells, and are increasingly recognized as having a central role in the establishment of T-cell memory and tolerance to inhaled antigens. DC form a closely meshed network within the respiratory mucosa and are rapidly recruited from the circulation in response to a variety of proinflammatory stimuli. Studies using animal models have highlighted the role of DC in both initiation and maintenance of allergic airway inflammation. Increased numbers of airway mucosal DC are found in both allergic rhinitis and asthma, and an increasing number of investigators have highlighted important functional differences between DC from atopic and normal individuals. This article reviews recent information on the involvement of DC in the pathogenesis of allergic airway disease and the means by which DC could be exploited as targets for therapy in asthma and allergic rhinitis.
Keyword Antigen-presenting cells
Dendritic cells
Immune tolerance
Allergy
Immunosuppression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 04 Mar 2009, 09:42:19 EST by Alexandra Cooney on behalf of School of Medicine