The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population

Kedda, M-A., Lose, F., Duffy, D., Bell, E., Thompson, P. J. and Upham, J. (2005) The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population. Thorax, 60 3: 211-214. doi:10.1136/thx.2004.028449


Author Kedda, M-A.
Lose, F.
Duffy, D.
Bell, E.
Thompson, P. J.
Upham, J.
Title The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population
Journal name Thorax   Check publisher's open access policy
ISSN 0040-6376
1468-3296
Publication date 2005-03
Sub-type Article (original research)
DOI 10.1136/thx.2004.028449
Volume 60
Issue 3
Start page 211
End page 214
Total pages 4
Editor Wisia Wedzicha
Sebastian Johnston
Place of publication London, United Kingdom
Publisher BMJ Publishing
Language eng
Subject 110203 Respiratory Diseases
110701 Allergy
Abstract Background: CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to play a role in the polarisation of T lymphocytes into Th1 and Th2 subsets, thereby influencing the cytokine profile and subsequent IgE production in response to antigen/allergen contact in allergic phenotypes. A functional C-159T polymorphism has been described in the promoter region of the gene and has been associated with increased gene expression, atopy, and nonatopic asthma in different ethnic populations. A study was undertaken to examine the association between the C-159T polymorphism and asthma, asthma severity, and atopy in a large Australian white population. Methods: PCR-RFLP analysis was used to characterise the C-159T polymorphism in mild (n = 264), moderate (n = 225) and severe (n = 79) asthmatic patients and non-asthmatic controls (n = 443), including atopic (n = 688) and non-atopic (n = 323) individuals. Association analyses were performed using x2 tests. Results: There was no association between the polymorphism and asthma (p = 0.468) or asthma severity (p = 0.727), and only a very weak association with atopy (p = 0.084). A meta-analysis of all studies conducted to date revealed similar genotypic frequencies in white ethnic populations and confirmed that there was no overall association with atopy (p = 0.52) or asthma (p = 0.23), although there was significant between study heterogeneity (p = 0.01). Conclusions: This study confirms that there is no association between the CD14 C-159T polymorphism and asthma or asthma severity and a weak association between this polymorphism and atopy in an adult population.
Keyword CD14
genetics
asthma
atopy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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