Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory

Upham, John W., Rate, Angela, Rowe, Julie, Kusel, Merci, Sly, Peter D. and Holt, Patrick G. (2006) Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory. Infection and Immunity, 74 2: 1106-1112. doi:10.1128/IAI.74.2.1106-1112.2006

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Author Upham, John W.
Rate, Angela
Rowe, Julie
Kusel, Merci
Sly, Peter D.
Holt, Patrick G.
Title Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2006-02
Sub-type Article (original research)
DOI 10.1128/IAI.74.2.1106-1112.2006
Open Access Status File (Publisher version)
Volume 74
Issue 2
Start page 1106
End page 1112
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
The capacity of the immune system in infants to develop stable T-cell memory in response to vaccination is attenuated, and the mechanism(s) underlying this developmental deficiency in humans is poorly understood. The present study focuses on the capacity for expression of in vitro recall responses to tetanus and diphtheria antigens in lymphocytes from 12-month-old infants vaccinated during the first 6 months of life. We demonstrate that supplementation of infant lymphocytes with "matured" dendritic cells (DC) cultured from autologous CD14+ precursors unmasks previously covert cellular immunity in the form of Th2-skewed cytokine production. Supplementation of adult lymphocytes with comparable prematured autologous DC also boosted vaccine-specific T-cell memory expression, but in contrast to the case for the infants, these cytokine responses were heavily Th1 skewed. Compared to adults, infants had significantly fewer circulating myeloid DC (P < 0.0001) and plasmacytoid DC (P < 0.0001) as a proportion of peripheral blood mononuclear cells. These findings suggest that deficiencies in the numbers of antigen-presenting cells and their functional competence at 12 months of age limit the capacity to express effector memory responses and are potentially a key factor in reduced vaccine responsiveness in infants.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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