Estimating the burden of disease attributable to lead exposure in South Africa in 2000

Norman, R., Mathee, A., Barnes, B., van der Merwe, L., Bradshaw, D. and South African Comparative Risk Assessment Collaborating Group (2007) Estimating the burden of disease attributable to lead exposure in South Africa in 2000. S A M J South African Medical Journal, 97 8: 773-780.

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Author Norman, R.
Mathee, A.
Barnes, B.
van der Merwe, L.
Bradshaw, D.
South African Comparative Risk Assessment Collaborating Group
Title Estimating the burden of disease attributable to lead exposure in South Africa in 2000
Journal name S A M J South African Medical Journal   Check publisher's open access policy
ISSN 0256-9574
Publication date 2007-08
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 97
Issue 8
Start page 773
End page 780
Total pages 8
Place of publication Pinelands, South Africa
Publisher Medical Association of South Africa
Language eng
Subject 1117 Public Health and Health Services
Formatted abstract
Objectives.
To estimate the burden of disease attributable to lead exposure in South Africa in 2000.

Design.
World Health Organization comparative risk assessment (CRA) methodology was followed. Recent community studies were used to derive mean blood lead concentrations in adults and children in urban and rural areas. Population-attributable fractions were calculated and applied to revised burden of disease estimates for the relevant disease categories for South Africa in the year 2000. Monte Carlo simulation-modelling techniques were used for the uncertainty analysis.

Setting.

South Africa.

Subjects.

Children under 5 and adults 30 years and older. Outcome measures. Cardiovascular mortality and disabilityadjusted life years (DALYs) in adults 30 years and older and mild mental disability DALYs in children under 5 years.

Results.

Lead exposure was estimated to cause 1 428 deaths (95% uncertainty interval 1 086-1 772) or 0.27% (95% uncertainty interval: 0.21 - 0.34%) of all deaths in South Africa in 2000. Burden of disease attributed to lead exposure was dominated by mild mental disability in young children, accounting for 75% of the total 58 939 (95% uncertainty interval 55 413 - 62 500) attributable DALYs. Cardiovascular disease in adults accounted for the remainder of the burden.

Conclusions.

Even with the phasing out of leaded petrol, exposure to lead from its ongoing addition to paint, paraoccupational exposure and its use in backyard ‘cottage industries’ will continue to be an important public health hazard in South Africa for decades. Young children, especially those from disadvantaged communities, remain particularly vulnerable to lead exposure and poisoning.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Excellence in Research Australia (ERA) - Collection
 
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Created: Mon, 02 Mar 2009, 15:24:42 EST by Ms Julie Schofield on behalf of Faculty Of Health Sciences