The Ministry of Health recognises health as a cross-sectoral issue. The strategic goal for their policy document, Intersectorial Action Framework for well-being and health (IAF), is: ...enhanced well-being and health of the peoples and communities of Timor-Leste through a shared understanding of public health problems and a combined approach of all of government along with the community itself to address key determinates of health. Its purpose is: to provide recognition by the Government of the Republic of Timor-Leste that the health and well-being of the peoples and communities of Timor-Leste can only be improved through a collaborative approach to recognition of priority health problems and their causes and subsequent public and individual action. In conjunction with this recognition, the IAF provides direction for joint government and community action to bring about positive changes in living and life conditions by coordinating efforts for positive change. It identifies key areas for action; guidelines and mechanisms for better coordination across various sectors and community in an integrated manner. This paper explores the cross-sectoral responses to TB, HIV/ sexually transmitted infections, diarrhoea and water and vector borne diseases.