Meeting the challenges of neuroimaging genetics

De Zubicaray, Greig I., Chiang, Ming-Chang, McMahon, Katie L., Shattuck, David W., Toga, Arthur W., Martin, Nicholas G., Wright, Margaret J. and Thompson, Paul M. (2008) Meeting the challenges of neuroimaging genetics. Brian Imaging and Behavior, 2 4: 258-263. doi:10.1007/s11682-008-9029-0

Author De Zubicaray, Greig I.
Chiang, Ming-Chang
McMahon, Katie L.
Shattuck, David W.
Toga, Arthur W.
Martin, Nicholas G.
Wright, Margaret J.
Thompson, Paul M.
Title Meeting the challenges of neuroimaging genetics
Journal name Brian Imaging and Behavior   Check publisher's open access policy
ISSN 1931-7557
Publication date 2008-12
Sub-type Article (original research)
DOI 10.1007/s11682-008-9029-0
Volume 2
Issue 4
Start page 258
End page 263
Total pages 6
Place of publication New York, NY, United States
Publisher Springer
Collection year 2009
Language eng
Subject 920111 Nervous System and Disorders
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Abstract As research encompassing neuroimaging and genetics gains momentum, extraordinary information will be uncovered on the genetic architecture of the human brain. However, there are significant challenges to be addressed first. Not the least of these challenges is to accomplish the sample size necessary to detect subtle genetic influences on the morphometry and function of the healthy brain. Aside from sample size, image acquisition and analysis methods need to be refined in order to ensure optimum sensitivity to genetic and complementary environmental influences. Then there is the vexing issue of interpreting the resulting data. We describe how researchers from the east coast of Australia and the west coast of America have embarked upon a collaboration to meet these challenges using data currently being collected from a large-scale twin study, and offer some opinions about future directions in the field.
Keyword Neuroimaging
High-angular resolution diffusion imaging (HARDI)
ACE modeling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 20 Feb 2009, 11:40:53 EST by Lesley-Jayne Jerrard on behalf of Faculty of Science