HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 5917: 1057-1060. doi:10.1126/science.1169841


Author Roberts, Tara L.
Idris, Adi
Dunn, Jasmyn A.
Kelly, Greg M.
Burnton, Carol M.
Hodgson, Samantha
Hardy, Lani. L.
Garceau, Valerie
Sweet, Matthew J.
Ross, Ian L.
Hume, David A.
Stacey, Katryn J.
Title HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2009-02-20
Year available 2009
Sub-type Article (original research)
DOI 10.1126/science.1169841
Volume 323
Issue 5917
Start page 1057
End page 1060
Total pages 4
Place of publication Washington, D.C., U.S.A
Publisher American Association for the Advancement of Science
Collection year 2009
Language eng
Subject 320202 Cellular Immunology
730101 Infectious diseases
060103 Cell Development, Proliferation and Death
Abstract The mammalian innate immune system is activated by foreign nucleic acids. Detection of double-stranded DNA (dsDNA) in the cytoplasm triggers characteristic antiviral responses and macrophage cell death. Cytoplasmic dsDNA rapidly activated caspase 3 and caspase 1 in bone marrow–derived macrophages. We identified the HIN-200 family member and candidate lupus susceptibility factor, p202, as a dsDNA binding protein that bound stably and rapidly to transfected DNA. Knockdown studies showed p202 to be an inhibitor of DNA-induced caspase activation. Conversely, the related pyrin domain–containing HIN-200 factor, AIM2 (p210), was required for caspase activation by cytoplasmic dsDNA. This work indicates that HIN-200 proteins can act as pattern recognition receptors mediating responses to cytoplasmic dsDNA.
Keyword Innate immune-responses
Cell-death
Family
Gene
Macrophages
Recognition
Infection
Signals
Domain
Lupus
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 19 Feb 2009, 16:45:20 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience