Stem cell options for kidney disease

Hopkins, C., Li, J., Rae, F. and Little, M. H. (2009) Stem cell options for kidney disease. Journal of Pathology, 217 2: 265-281. doi:10.1002/path.2477


Author Hopkins, C.
Li, J.
Rae, F.
Little, M. H.
Title Stem cell options for kidney disease
Journal name Journal of Pathology   Check publisher's open access policy
ISSN 0022-3417
1096-9896
Publication date 2009-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/path.2477
Volume 217
Issue 2
Start page 265
End page 281
Total pages 17
Place of publication West Sussex, United Kingdom
Publisher John Wiley and Sons
Collection year 2009
Language eng
Subject 060103 Cell Development, Proliferation and Death
970106 Expanding Knowledge in the Biological Sciences
C1
060199 Biochemistry and Cell Biology not elsewhere classified
Abstract Chronic kidney disease (CKD) is increasing at the rate of 6-8% per annum in the US alone. At present, dialysis and transplantation remain the only treatment options. However, there is hope that stem cells and regenerative medicine may provide additional regenerative options for kidney disease. Such new treatments might involve induction of repair using endogenous or exogenous stem cells or the reprogramming of the organ to reinitiate development. This review addresses the current state of understanding with respect to the ability of non-renal stem cell sources to influence renal repair, the existence of endogenous renal stem cells and the biology of normal renal repair in response to damage. It also examines the remaining challenges and asks the question of whether there is one solution for all forms of renal disease. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Keyword Kidney disease
CD133
Neonephrogenesis
Stem cell markers
Renal repair
Renal disease
Regenerative medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Published Online: Oct 20 2008

 
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Created: Fri, 13 Feb 2009, 21:15:57 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience