In vitro biocompatibility of different polyester membranes

Vaquette, C., Fawzi-Grancher, S., Lavalle, P., Frochot, C., Viriot, M.-L., Muller, S. and Wang, X. (2006) In vitro biocompatibility of different polyester membranes. Bio-medical materials and engineering [electronic resource], 16 4 Suppl.: S131-S136.

Author Vaquette, C.
Fawzi-Grancher, S.
Lavalle, P.
Frochot, C.
Viriot, M.-L.
Muller, S.
Wang, X.
Title In vitro biocompatibility of different polyester membranes
Journal name Bio-medical materials and engineering [electronic resource]   Check publisher's open access policy
ISSN 0959-2989
Publication date 2006
Sub-type Article (original research)
Volume 16
Issue 4 Suppl.
Start page S131
End page S136
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher IOS Press
Language eng
Subject 090301 Biomaterials
Abstract Nowadays, synthetic biodegradable polymers, such as aliphatic polyesters, are largely used in tissue engineering. They provide several advantages compared to natural materials which use is limited by immunocompatibility, graft availability, etc. In this work, poly(L-lactic) acid (PLLA), poly(DL-lactic) acid (PDLA), poly-ε-caprolactone (PCL), poly(L-lactic)-co-caprolactone (molar ratio 70/30) (PLCL) were selected because of their common use in tissue engineering. The membranes were elaborated by solvent casting. Membrane morphology was investigated by atomic force microscopy. The membranes were seeded with human fibroblasts from cell line CRL 2703 in order to evaluate the biocompatibility by the Alamar blue test. The roughness of the membranes ranged from 4 nm for PDLA to 120 nm and they presented very smooth surface except for PCL which beside a macroscopic structure due to its hydrophobicity. Human fibroblasts proliferated over 28 days on the membranes proving the non-in vitro toxicity of the materials and of the processing method. A further step will be the fabrication of three-dimensional scaffold for tissue engineering and the treatment of the scaffolds to augment cell adhesion.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Created: Thu, 12 Feb 2009, 15:40:57 EST by Ms Lynette Adams on behalf of Aust Institute for Bioengineering & Nanotechnology