Daphniyunnines A−E, Alkaloids from Daphniphyllum yunnanense

Zhang, Hua, Yang, Sheng-Ping, Fan, Cheng-Qi, Ding, Jian and Yue, Jian-Min (2006) Daphniyunnines A−E, Alkaloids from Daphniphyllum yunnanense. Journal of Natural Products, 69 4: 553-557. doi:10.1021/np050490e


Author Zhang, Hua
Yang, Sheng-Ping
Fan, Cheng-Qi
Ding, Jian
Yue, Jian-Min
Title Daphniyunnines A−E, Alkaloids from Daphniphyllum yunnanense
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2006-04
Sub-type Article (original research)
DOI 10.1021/np050490e
Volume 69
Issue 4
Start page 553
End page 557
Total pages 5
Place of publication Cincinnati, Ohio
Publisher American Chemical Society
Language eng
Subject 030502 Natural Products Chemistry
Abstract The first chemical study on the stems and leaves of Daphniphyllum yunnanense led to the isolation of five new alkaloids, daphniyunnines A−E (1−5). Daphniyunnines B−E (2−5) are four unusual C-22 nor-Daphniphyllum alkaloids. The structures of these alkaloids were characterized by spectroscopic methods, especially 2D NMR techniques. A single-crystal X-ray diffraction analysis was used to confirm the structure of 1. Daphniyunnine D (4) showed cytotoxicity against two tumor cell lines, P-388 and A-549, with IC50 values of 3.0 and 0.6 μM, respectively.
Formatted abstract
The first chemical study on the stems and leaves of Daphniphyllum yunnanense led to the isolation of five new alkaloids, daphniyunnines A−E (1−5). Daphniyunnines B−E (2−5) are four unusual C-22 nor-Daphniphyllum alkaloids. The structures of these alkaloids were characterized by spectroscopic methods, especially 2D NMR techniques. A single-crystal X-ray diffraction analysis was used to confirm the structure of 1. Daphniyunnine D (4) showed cytotoxicity against two tumor cell lines, P-388 and A-549, with IC50 values of 3.0 and 0.6 μM, respectively.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 52 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 55 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 11 Feb 2009, 11:43:16 EST by Joanne Mellor on behalf of Institute for Molecular Bioscience