Cross-presentation of a human malaria CTL epitope is conformation dependent

Pratoa, S., Fleminga, J., Schmidta, C.W., Corradinb, G. and Lopez, J. A. (2006) Cross-presentation of a human malaria CTL epitope is conformation dependent. Molecular Immunology, 43 13: 2031-2036. doi:10.1016/j.molimm.2005.12.014

Author Pratoa, S.
Fleminga, J.
Schmidta, C.W.
Corradinb, G.
Lopez, J. A.
Title Cross-presentation of a human malaria CTL epitope is conformation dependent
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
Publication date 2006-05
Sub-type Article (original research)
DOI 10.1016/j.molimm.2005.12.014
Volume 43
Issue 13
Start page 2031
End page 2036
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 1107 Immunology
Formatted abstract
Little is known about the role of conformation on the antigen processing by antigen presenting cells. Using a well-defined antigen containing two disulfide bridges, the synthetic C-terminal fragment 282–383 derived from Plasmodium falciparum circumsporozoite protein (PfCS 282–383), we show that the reduced form is presented in vitro more efficiently than its oxidized counterpart, inducing stronger CTL recognition. In addition, only the reduced form can be presented by the TAP independent T2 cell line. Thus, the reduced form is processed by TAP dependent and independent pathways.
Keyword Antigen presentation
3D structure
Circumsporozoite protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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