Population of HLA-DR+ Immature Cells Accumulate in the Blood Dendritic Cell Compartment of Patients with Different Types of Cancer

Pinzon-Charry, A., Ho, C. S . K., Laherty, R., Maxwell, T., Walker, D., Gardiner, R. A., O'Connor, L., Pyke, C., Schmidt, C. W., Furnival, C. and Lopez, J. A. (2005). Population of HLA-DR+ Immature Cells Accumulate in the Blood Dendritic Cell Compartment of Patients with Different Types of Cancer. In: Tissue Antigens. 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop. The 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop: 'Genetics and The Immune Response', Melbourne, Australia, (484-484). 29 November - 2 December 2005. doi:10.1111/j.1399-0039.2005.00523.x


Author Pinzon-Charry, A.
Ho, C. S . K.
Laherty, R.
Maxwell, T.
Walker, D.
Gardiner, R. A.
O'Connor, L.
Pyke, C.
Schmidt, C. W.
Furnival, C.
Lopez, J. A.
Title of paper Population of HLA-DR+ Immature Cells Accumulate in the Blood Dendritic Cell Compartment of Patients with Different Types of Cancer
Conference name The 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop: 'Genetics and The Immune Response'
Conference location Melbourne, Australia
Conference dates 29 November - 2 December 2005
Proceedings title Tissue Antigens. 'Genetics and The Immune Response' Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop   Check publisher's open access policy
Journal name Tissue Antigens   Check publisher's open access policy
Place of Publication Copenhagen
Publication Year 2005
DOI 10.1111/j.1399-0039.2005.00523.x
ISSN 0001-2815
1399-0039
Volume 66
Issue 5
Start page 484
End page 484
Total pages 1
Language eng
Abstract/Summary Dendritic cell (DC) defects are an important component of immunosuppression in cancer. Here, we assessed whether cancer could affect circulating DC populations and its correlation with tumour progression. The blood DC compartment was evaluated in 136 patients with breast, prostate cancer and malignant glioma. Phenotypic, quantitative and functional analyses were performed at various stages of disease. Patients had significantly fewer circulating myeloid (CD11c+DC) and lymphoid (CD123+DC) DC, and a concurrent accumulation of CD11cCD123 immature cells which expressed high levels of HLA-DR (DR+IC). Although DR+IC exhibited limited expression of markers ascribed to mature hematopoietic lineages, expression of HLA-DR, CD40 and CD86 suggested a role as antigen presenting cells. Nevertheless, DR+IC had a reduced capacity to capture antigen and elicited poor proliferation and IFN-g secretion by T-lymphocytes. Importantly, increased numbers of DR+IC correlated with disease status. Patients with metastatic breast cancer showed a larger number of DR+IC in the circulation than patients with local/nodal disease. Similarly, in patients with fully-resected glioma, the proportion of DR+IC in blood increased when evaluation indicated tumour recurrence. The reduction of blood DC correlating with the accumulation of a population of immature cells with poor immunological function may be associated with the increased immunodeficiency observed in cancer. We have identified the same population in healthy individuals although here it represents a significantly lower proportion of the blood DC compartment. We investigated their functional properties and established that DR+IC exhibit a significant reduction in their antigen presenting capacity similar to their counterparts in patients with cancer. I nterestingly, DR+IC are responsive to stimulation with CD40L but not to other maturation agents commonly used for immunotherapy. Our findings highlight the importance of DC in cancer progression and provide an efficient strategy to overcome DC dysfunction for novel DC-based immunotherapy.
Subjects 110709 Tumour Immunology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Meeting Abstract number: 385

 
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Created: Tue, 10 Feb 2009, 16:41:27 EST by Ms Lynette Adams on behalf of Institute for Molecular Bioscience