Dendritic cell immunotherapy for breast cancer

Pinzon-Charry, Alberto, Schmidt, Chris and Lopez, Jose Alejandro (2006) Dendritic cell immunotherapy for breast cancer. Expert Opinion on Biological Therapy, 6 6: 591-604. doi:10.1517/14712598.6.6.591

Author Pinzon-Charry, Alberto
Schmidt, Chris
Lopez, Jose Alejandro
Title Dendritic cell immunotherapy for breast cancer
Journal name Expert Opinion on Biological Therapy   Check publisher's open access policy
ISSN 1471-2598
Publication date 2006-06
Sub-type Article (original research)
DOI 10.1517/14712598.6.6.591
Volume 6
Issue 6
Start page 591
End page 604
Total pages 14
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 110709 Tumour Immunology
Abstract Novel adjuvant therapies are urgently needed to complement the existing treatment options for breast cancer. The advent of the use of dendritic cells (DCs) for cancer immunotherapy provides a unique opportunity to overcome the relative non-immunogenic property of breast tumours and address the underlying immunodeficiency. To date, the success of this approach has been limited, possibly due to the targeting of specific tumour antigens that rapidly mutate and, thus, become undetectable to the immune system. A more efficient approach would include preparations encompassing multiple antigens, such as those provided by loading of whole tumour cells or tumour RNA. It is proposed that targeting mammary stem cells responsible for resistance to chemo/immunotherapy, through the expression of a broad array of wild-type and mutated tumour antigens in the context of DCs, will become a mainstay for immunotherapy of breast cancer.
Keyword Adjuvant therapy
Breast cancer
Dendritic cells
Stem cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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Created: Tue, 10 Feb 2009, 16:17:59 EST by Ms Lynette Adams on behalf of Institute for Molecular Bioscience