Cdx2 Is Essential for Axial Elongation in Mouse Development

Chawengsaksophak, Kallayanee, de Graaff, Wim, Rossant, Janet, Deschamps, Jacqueline, Beck, Felix and Ruddle, Francis H. (2004) Cdx2 Is Essential for Axial Elongation in Mouse Development. Proceedings of the National Academy of Sciences of the United States of America, 101 20: 7641-7645. doi:10.1073/pnas.0401654101


Author Chawengsaksophak, Kallayanee
de Graaff, Wim
Rossant, Janet
Deschamps, Jacqueline
Beck, Felix
Ruddle, Francis H.
Title Cdx2 Is Essential for Axial Elongation in Mouse Development
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2004
Sub-type Article (original research)
DOI 10.1073/pnas.0401654101
Open Access Status Not Open Access
Volume 101
Issue 20
Start page 7641
End page 7645
Total pages 5
Place of publication Washington, D.C.
Publisher National Academy of Sciences
Language eng
Subject 060403 Developmental Genetics (incl. Sex Determination)
Abstract Inactivation of Cdx2 leads to preimplantation embryonic lethality. Rescue of the implantation defect by tetraploid fusion established that Cdx2 is necessary for trophoblastic development, vasculogenesis in the yolk sac mesoderm, allantoic growth, and chorioallantoic fusion. "Rescued" Cdx2 mutants die at late gastrulation stages because of failure of placental development. Cdx2 is also needed for the completion of the normal process of gastrulation and tail bud elongation. Presegmental paraxial mesoderm is severely restricted in amount and somites posterior to somite 5 are abnormal. The Cdx2 mutation, like mutations impairing Wnt and Fgf signaling, causes posterior truncations and disturbs axial patterning of the embryonic structures, indicated by changes in the Hox expression domains. The gene appears to be important in the integration of the pathways controlling embryonic axial elongation, and anterior-posterior patterning.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 10 Feb 2009, 14:51:03 EST by Ms Sarada Rao on behalf of Institute for Molecular Bioscience