Dendritic cell immunotherapy for stage IV melanoma

O'Rourke, Michael G. E., Johnson, Maree K., Lanagan, Catherine M., See, Janet L., O'Connor, Linda E., Slater, Gregory J., Thomas, David, Lopez, Jose Alejandro, Martinez, Nathan R., Ellem, Kay A. O. and Schmidt, Christopher W. (2007) Dendritic cell immunotherapy for stage IV melanoma. Melanoma research, 17 5: 316-322. doi:10.1097/CMR.0b013e3282c3a73b


Author O'Rourke, Michael G. E.
Johnson, Maree K.
Lanagan, Catherine M.
See, Janet L.
O'Connor, Linda E.
Slater, Gregory J.
Thomas, David
Lopez, Jose Alejandro
Martinez, Nathan R.
Ellem, Kay A. O.
Schmidt, Christopher W.
Title Dendritic cell immunotherapy for stage IV melanoma
Journal name Melanoma research   Check publisher's open access policy
ISSN 0960-8931
Publication date 2007-10
Sub-type Article (original research)
DOI 10.1097/CMR.0b013e3282c3a73b
Volume 17
Issue 5
Start page 316
End page 322
Total pages 7
Place of publication London
Publisher Lippincott Williams & Wilkins
Language eng
Subject 110709 Tumour Immunology
Abstract Active boosting of the antitumour immune response of patients with solid malignancies has been tested in a large number of trials. Isolated complete clinical responses have been reported, however, they have not been replicated in subsequent studies. We recently reported objective clinical responses to a dendritic cell/irradiated autologous tumour cell 'vaccine' in patients with distant metastatic (stage IV) melanoma. Here we describe our experience in a second cohort of patients with stage IV melanoma, using this dendritic cell-based immunotherapy in a cryopreserved format. Of 46 patients enroled into the study, three had complete remission of all detectable disease, and a further three had partial clinical responses. These data confirm that dendritic cell-based immunotherapy has potential as a therapy in a limited number of patients with stage IV melanoma. To our knowledge, this is the first demonstration that cryopreserved dendritic cells can elicit complete clinical responses in patients with advanced cancer. Our observations support randomized controlled trials to validate the findings.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 10 Feb 2009, 14:43:07 EST by Ms Lynette Adams on behalf of Institute for Molecular Bioscience