Scholastic modelling and simulation of coupled autoregulated oscillators in a multicellular environment: the her1/her7 genes

Leier, A., Burrage, K. and Burrage, P. M. (2007). Scholastic modelling and simulation of coupled autoregulated oscillators in a multicellular environment: the her1/her7 genes. In: Proceedings- ICCS 2007. Computational Science – ICCS 2007 7th International Conference, Beijing, China, (778-785). 27-30 May 2007. doi:10.1007/978-3-540-72584-8


Author Leier, A.
Burrage, K.
Burrage, P. M.
Title of paper Scholastic modelling and simulation of coupled autoregulated oscillators in a multicellular environment: the her1/her7 genes
Conference name Computational Science – ICCS 2007 7th International Conference
Conference location Beijing, China
Conference dates 27-30 May 2007
Proceedings title Proceedings- ICCS 2007   Check publisher's open access policy
Journal name Computational Science - ICCS 2007, Pt 1, Proceedings   Check publisher's open access policy
Place of Publication Berlin / Heidelberg
Publisher Springer
Publication Year 2007
Sub-type Fully published paper
DOI 10.1007/978-3-540-72584-8
ISBN 978-3-540-72583-1
ISSN 0302-9743
Volume 4487/2007
Start page 778
End page 785
Total pages 8
Language eng
Abstract/Summary Abstract. Delays are an important feature in temporal models of genetic regulation due to slow biochemical processes such as transcription and translation. In this paper we show how to model intrinsic noise effects in a delayed setting. As a particular application we apply these ideas to modelling somite segmentation in zebrafish across a number of cells in which two linked oscillatory genes her1 and her7 are synchronized via Notch signalling between the cells.
Subjects 010202 Biological Mathematics
Keyword delay stochastic simulation algorithm
coupled regulatory systems
multicellular environment
multiscale modelling
Q-Index Code E1

 
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Created: Fri, 06 Feb 2009, 12:55:20 EST by Paul Rollo on behalf of Institute for Molecular Bioscience