A role for caveolae in cell migration

Navarro, Angels, Anand-Apte, Bela and Parat, Marie-Odile (2004) A role for caveolae in cell migration. The FASEB Journal, 18 15: 1801-1811.


Author Navarro, Angels
Anand-Apte, Bela
Parat, Marie-Odile
Title A role for caveolae in cell migration
Journal name The FASEB Journal   Check publisher's open access policy
ISSN 0892-6638
1530-6860
Publication date 2004-12
Sub-type Article (original research)
DOI 10.1096/fj.04-2516rev
Volume 18
Issue 15
Start page 1801
End page 1811
Total pages 12
Editor Gerald Weissmann
Place of publication Bethesda, MD, United States of America
Publisher Federation of American Societies for Experimental Biology
Language eng
Subject 0601 Biochemistry and Cell Biology
Abstract Caveolae are specialized plasma membrane subdomains capable of transport and sophisticated compartmentalization of cell signaling. Numerous cell functions, including cell type-specific functions, involve caveolae and require caveolin-1, the major protein component of these organelles. Caveolae are particularly abundant in endothelial cells and participate in endothelial transcytosis, vascular permeability, vasomotor tone control, and vascular reactivity. Caveolin-1 drives the formation of plasma membrane caveolae and anchors them to the actin cytoskeleton, modulates cell interaction with the extracellular matrix, pulls together and regulates signaling molecules, and transports cholesterol. Via these functions, caveolin-1 might play an important role in cell movement through control of cell membrane composition and membrane surface expansion, polarization of signaling molecules and matrix proteolysis, and/or cytoskeleton remodeling. Caveolae and caveolin-1 are polarized in migrating endothelial cells, indicating they may play a role in cell motility. Several studies have shown that manipulation of caveolin-1 expression affects cell migration in a complex way. We are reviewing the current data and hypotheses in favor of an essential role for caveolae in cell migration.
Keyword Biology, experimental
Biology - research
angiogenesis
caveolin-1
endothelial cell
motility
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Pharmacy Publications
 
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