Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery

Wang, Yiwei, Chang, Hsin-I, Wertheim, David F., Jones, Allan S., Jackson, Chris and Coombes, Allan G. A. (2007) Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28 31: 4619-4627. doi:10.1016/j.biomaterials.2007.07.006


Author Wang, Yiwei
Chang, Hsin-I
Wertheim, David F.
Jones, Allan S.
Jackson, Chris
Coombes, Allan G. A.
Title Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
Publication date 2007-11
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2007.07.006
Volume 28
Issue 31
Start page 4619
End page 4627
Total pages 19
Editor D. F. Williams
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 111504 Pharmaceutical Sciences
090301 Biomaterials
Abstract Microporous, biocomposite matrices comprising a continuous phase of poly(ε-caprolactone) (PCL) and a dispersed phase of lactose or gelatin particles with defined size range (45–90, 90–125 and 125–250 μm) were produced by precipitation casting from solutions of PCL in acetone. Scanning electron microscopy (SEM) analysis revealed a characteristic surface morphology of particulates interspersed amongst crystalline lamellae of the polymer phase. Rapid release of around 80% of the lactose content occurred in PBS at 37 °C in 3 days, whereas biocomposites containing gelatin particles of size range 90–125 and 125–250 μm, respectively, displayed gradual and highly efficient release of around 90% of the protein phase over 21 days. A highly porous structure was obtained on extraction of the water-soluble phase. Micro-computed tomography (Micro-CT) and image analysis enabled 3-D visualisation and quantification of the internal pore size distribution. A maximum fractional pore area of 10.5% was estimated for gelatin-loaded matrices. Micro-CT analysis confirmed the presence of an extensive system of macropores, sufficiently connected to permit protein diffusion, but an absence of high volume, inter-pore channels. Thus tissue integration would be confined to the matrix surface initially if the designs investigated were used as tissue-engineering scaffolds, with the core potentially providing a depot system for controlled delivery of growth factors.
Keyword Biocomposite
Polycaprolactone
Protein delivery
Porosity
Scaffold;
Micro-CT
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Wed, 04 Feb 2009, 13:57:54 EST by Ms Karen Naughton on behalf of School of Pharmacy