New insights into SRY regulation through identification of 5' conserved sequences

Ross, Diana G.F., Bowles, Josephine, Koopman, Peter and Lehnert, Sigrid (2008) New insights into SRY regulation through identification of 5' conserved sequences. BMC Molecular Biology, 9 85.1-85.15. doi:10.1186/1471-2199-9-85


Author Ross, Diana G.F.
Bowles, Josephine
Koopman, Peter
Lehnert, Sigrid
Title New insights into SRY regulation through identification of 5' conserved sequences
Journal name BMC Molecular Biology   Check publisher's open access policy
ISSN 1471-2199
Publication date 2008-10-14
Year available 2008
Sub-type Article (original research)
DOI 10.1186/1471-2199-9-85
Open Access Status DOI
Volume 9
Start page 85.1
End page 85.15
Total pages 15
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background:
 
SRY is the pivotal gene initiating male sex determination in most mammals, but how its expression is regulated is still not understood. In this study we derived novel SRY 5' flanking genomic sequence data from bovine and caprine genomic BAC clones.

Results:  
We identified four intervals of high homology upstream of SRY by comparison of human, bovine, pig, goat and mouse genomic sequences. These conserved regions contain putative binding sites for a large number of known transcription factor families, including several that have been implicated previously in sex determination and early gonadal development.

Conclusion:  
Our results reveal potentially important SRY regulatory elements, mutations in which might underlie cases of idiopathic human XY sex reversal.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 85. Published: online 14 October 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
 
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Created: Tue, 03 Feb 2009, 11:39:53 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience