Baf60c is a nuclear Notch signaling component required for the establishment of left–right asymmetry

Takeuchi, Jun K., Lickert, Heiko, Bisgrove, Brent W., Sun, Xin, Yamamoto, Masamichi, Chawengsaksophak, Kallayanee, Hamada, Hiroshi, Yost, H. Joseph, Rossant, Janet and Bruneau, Benoit G. (2007) Baf60c is a nuclear Notch signaling component required for the establishment of left–right asymmetry. Proceedings of the National Academy of Sciences of the United States of America, 104 3: 846-851. doi:10.1073/pnas.0608118104


Author Takeuchi, Jun K.
Lickert, Heiko
Bisgrove, Brent W.
Sun, Xin
Yamamoto, Masamichi
Chawengsaksophak, Kallayanee
Hamada, Hiroshi
Yost, H. Joseph
Rossant, Janet
Bruneau, Benoit G.
Title Baf60c is a nuclear Notch signaling component required for the establishment of left–right asymmetry
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2007-01-16
Sub-type Article (original research)
DOI 10.1073/pnas.0608118104
Open Access Status Not Open Access
Volume 104
Issue 3
Start page 846
End page 851
Total pages 6
Place of publication Washington, D.C.
Publisher National Academy of Sciences of the U.S.
Language eng
Subject 060403 Developmental Genetics (incl. Sex Determination)
Abstract Notch-mediated induction of Nodal at the vertebrate node is a critical step in initiating left–right (LR) asymmetry. In mice and zebrafish we show that Baf60c, a subunit of the Swi/Snf-like BAF chromatin remodeling complex, is essential for establishment of LR asymmetry. Baf60c knockdown mouse embryos fail to activate Nodal at the node and also have abnormal node morphology with mixing of crown and pit cells. In cell culture, Baf60c is required for Notch-dependent transcriptional activation and functions to stabilize interactions between activated Notch and its DNA-binding partner, RBP-J. Brg1 is also required for these processes, suggesting that BAF complexes are key components of nuclear Notch signaling. We propose a critical role for Baf60c in Notch-dependent transcription and LR asymmetry.
Keyword Chromatin
Swi/Snf
node
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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