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Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation
Svingen, Terje, Beverdam, Annemiek, Verma, Pali, Wilhelm, Dagmar and Koopman, Peter (2007) Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation. International Journal of Developmental Biology, 51 : 255-258.
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| Author(s) |
Svingen, Terje
Beverdam, Annemiek
Verma, Pali
Wilhelm, Dagmar
Koopman, Peter
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| Title |
Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation
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| Journal name |
International Journal of Developmental Biology
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| Publication date |
2007
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| Year available |
2007
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| Volume number |
51
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| ISSN |
0214-6282
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| Start page |
255
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| End page |
258
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| Total pages |
4
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| Place of publication |
Bilbao, Spain
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| Publisher |
University of the Basque Country Press
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| Language |
eng
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| Subject |
060405 Gene Expression (incl. Microarray and other genome-wide approaches)
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| Abstract |
Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression profile of Aard during gonad development. The period of elevated mRNA expression coincides with early differentiation of the testis and is limited to Sertoli cells of the developing testis cords. Although low levels of Aard transcripts were detected in other tissues by quantitative RT-PCR assays, high levels of Aard expression is specific to the testis in both embryonic and adult mice.
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| Keyword(s) |
Aard
gonad
sex differentiation
testis cord
Sertoli cell
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