Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum

Salim, Angela A., Sua, Bao-Ning, Chaia, Hee-Byung, Riswanb, Soedarsono, Kardonoc, Leonardus B. S., Ruskandib, Agus, Farnsworthd, Norman R., Swansond, Steven M. and Kinghorna, A. Douglas (2007) Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum. Tetrahedron letters, 48 10: 1849-1853. doi:10.1016/j.tetlet.2007.01.017


Author Salim, Angela A.
Sua, Bao-Ning
Chaia, Hee-Byung
Riswanb, Soedarsono
Kardonoc, Leonardus B. S.
Ruskandib, Agus
Farnsworthd, Norman R.
Swansond, Steven M.
Kinghorna, A. Douglas
Title Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum
Journal name Tetrahedron letters   Check publisher's open access policy
ISSN 0040-4039
Publication date 2007-03-05
Year available 2007
Sub-type Article (original research)
DOI 10.1016/j.tetlet.2007.01.017
Volume 48
Issue 10
Start page 1849
End page 1853
Total pages 5
Place of publication Oxford
Publisher Pergamon Press
Language eng
Subject 030401 Biologically Active Molecules
030502 Natural Products Chemistry
Abstract Four new compounds having an unusual 1,7-dioxadispiro[5.1.5.2]-12-ene-11-one tricyclic ring system (1–4), their potential precursor, 5R-hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1–4, 6, and 7 showed cytotoxic activity against several human cancer cell lines.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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