Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy

Kim, Soyoung, Salim, Angela A., Swanson, Steven M. and Douglas Kinghorn, A. (2006) Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry, 6 4: 319-345. doi:10.2174/187152006777698123

Author Kim, Soyoung
Salim, Angela A.
Swanson, Steven M.
Douglas Kinghorn, A.
Title Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy
Journal name Anti-Cancer Agents in Medicinal Chemistry   Check publisher's open access policy
ISSN 1871-5206
Publication date 2006-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/187152006777698123
Volume 6
Issue 4
Start page 319
End page 345
Total pages 27
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Subject 030401 Biologically Active Molecules
030502 Natural Products Chemistry
030503 Organic Chemical Synthesis
Abstract During the past few years, a group of cyclopenta[b]benzofurans from the plant genus Aglaia has received broad scientific attention as interesting natural product lead compounds with potential anticancer and insecticidal activities. Since the first cyclopenta[b]benzofuran derivative, rocaglamide, from Aglaia elliptifolia, was found to exhibit antileukemic activity in a murine in vivo model, the genus Aglaia has been subjected to further investigation. Over 40 cyclopenta [b]benzofurans have been tested against different human cancer cell lines, and the cumulative results provide some important clues as to how to improve their activity through modification of their chemical structures. The semisynthesis and total synthesis of the cyclopenta [b]benzofurans have been conducted. Although the ultimate molecular target(s) responsible for their antiproliferative activity has not yet been identified, studies on their cellular mechanism of action have demonstrated that some of these compounds inhibit TNF-α or PMA-induced NF-κB activity in T-lymphocytes and induce apoptosis in different human cancer cell lines. Based on the published data thus far, cyclopenta[b]benzofurans offer excellent potential as therapeutic agent candidates in cancer chemotherapy, even if much work still remains to be done for their further development.
Keyword murine in vivo test systems
antiproliferative agents
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes 'Anti-Cancer Agents in Medicinal Chemistry' formerly titled 'Current Medicinal Chemistry - Anti-Cancer Agents'

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Created: Thu, 29 Jan 2009, 14:57:07 EST by Gina Velli on behalf of Institute for Molecular Bioscience