The endosteal bone niche contains macrophages that regulate osteoblast function

Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. In: Bone. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, (S127-S127). 24-29 June 2007. doi:10.1016/j.bone.2007.04.166


Author Pettit, A. R.
Chang, M. K.
Alexander, K. A.
Wu, A. C.
Hume, D. A.
Raggatt, L. J.
Title of paper The endosteal bone niche contains macrophages that regulate osteoblast function
Conference name 17th Scientific Meeting of the International Bone & Mineral Society
Conference location Montreal, Canada
Conference dates 24-29 June 2007
Proceedings title Bone   Check publisher's open access policy
Journal name Bone   Check publisher's open access policy
Place of Publication New York
Publisher Elsevier Science
Publication Year 2007
DOI 10.1016/j.bone.2007.04.166
ISSN 8756-3282
1873-2763
Volume 40
Issue 6
Start page S127
End page S127
Total pages 1
Language eng
Abstract/Summary Recent studies highlight the endosteal niche as a complex and specialized environment and that osteoblasts as well as the bone matrix and mineral content are important for lodgement and maintenance of haematopoietic stem cells (HSC) in this zone (Cell and Nature, 2006). However, older data demonstrating that macrophages cluster haematopoietic progenitors in the bone marrow (BM) and that a population of F4/80+ cells is associated with osteal surfaces has not been considered in the endosteal niche model. We confirmed that F4/80+ cells are interdigitated throughout the endosteal niche and display either stellate or spindle-like morphology with extensive cell processes.
Subjects 110314 Orthopaedics
110704 Cellular Immunology
Keyword Cell & Molecular Biology
Osteoporosis
Rheumatology,
Bone Mineralization
Osteoimmunology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Presentation Number: 039

 
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Created: Wed, 21 Jan 2009, 16:01:59 EST by Ms Karen Naughton on behalf of Institute for Molecular Bioscience