IMGT, the international ImMunoGeneTics information system

Lefranc, Marie-Paule, Giudicelli, Veronique, Kaas, Quentin, Clément, Oliver, Duprat, Elodie, Jabado-Michaloud, Joumana, Scaviner, Dominqiue, Ginestoux, Chantal, Chaume, Denys and Lefranc, Gerard (2005) IMGT, the international ImMunoGeneTics information system. Nucleic Acids Research, 33 Database Issue Supplement 1: D593-D597. doi:10.1093/nar/gki065

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Author Lefranc, Marie-Paule
Giudicelli, Veronique
Kaas, Quentin
Clément, Oliver
Duprat, Elodie
Jabado-Michaloud, Joumana
Scaviner, Dominqiue
Ginestoux, Chantal
Chaume, Denys
Lefranc, Gerard
Title IMGT, the international ImMunoGeneTics information system
Journal name Nucleic Acids Research   Check publisher's open access policy
ISSN 0305-1048
1362-4962
Publication date 2005-01
Year available 2005
Sub-type Article (original research)
DOI 10.1093/nar/gki065
Open Access Status DOI
Volume 33
Issue Database Issue Supplement 1
Start page D593
End page D597
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 060102 Bioinformatics
Abstract The international ImMunoGeneTics information system® (IMGT) (http://imgt.cines.fr), created in 1989, by the Laboratoire d'ImmunoGénétique Moléculaire LIGM (Université Montpellier II and CNRS) at Montpellier, France, is a high-quality integrated knowledge resource specializing in the immunoglobulins (IGs), T cell receptors (TRs), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune systems (RPI) that belong to the immunoglobulin superfamily (IgSF) and to the MHC superfamily (MhcSF). IMGT includes several sequence databases (IMGT/LIGM-DB, IMGT/PRIMER-DB, IMGT/PROTEIN-DB and IMGT/MHC-DB), one genome database (IMGT/GENE-DB) and one three-dimensional (3D) structure database (IMGT/3Dstructure-DB), Web resources comprising 8000 HTML pages (IMGT Marie-Paule page), and interactive tools. IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on the IMGT-ONTOLOGY concepts. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in normal physiological and pathological situations. IMGT is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas, myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow up of residual diseases) and therapeutical approaches (graft, immunotherapy and vaccinology). IMGT is freely available at http://imgt.cines.fr.
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 21 Jan 2009, 13:04:02 EST by Maryanne Watson on behalf of Institute for Molecular Bioscience