Digital RNA regulation of complex organisms

Mattick, John S. (2004) Digital RNA regulation of complex organisms. Gene Therapy and Regulation, 2 4: 313-319. doi:10.1163/1568558043967517

Author Mattick, John S.
Title Digital RNA regulation of complex organisms
Journal name Gene Therapy and Regulation   Check publisher's open access policy
ISSN 1388-9532
Publication date 2004-12
Year available 2004
Sub-type Article (original research)
DOI 10.1163/1568558043967517
Volume 2
Issue 4
Start page 313
End page 319
Total pages 7
Place of publication Utrecht ; Boston
Publisher VSP
Language eng
Subject 060407 Genome Structure and Regulation
Abstract Proteins and their products are the analog components of cells. However the number of protein-coding genes in humans is not markedly different from that of a simple nematode worm, despite the vast differences in their developmental complexity. On the other hand, most of the human genome is transcribed, mainly into non-protein-coding RNAs. Both logic and emerging evidence suggest that these RNAs are not junk, but form an extensive regulatory network that was a necessary adaptation to solve the vastly expanded regulatory requirements of complex organisms, and that these RNAs now comprise a hidden layer of feed-forward control signals that direct the epigenetic trajectories of differentiation and development.
Keyword proteins
protein coding genes
Non-coding Rna
Ultraconserved Sequences
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
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Created: Mon, 19 Jan 2009, 16:29:25 EST by Ms Karen Naughton on behalf of Institute for Molecular Bioscience