IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?

Kaas, Quentin, Ehrenmann, Francois and Lefranc, Marie-Paule (2007) IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?. Briefings in Functional Genomics and Proteomics, 6 4: 253-264. doi:10.1093/bfgp/elm032

Author Kaas, Quentin
Ehrenmann, Francois
Lefranc, Marie-Paule
Title IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
Journal name Briefings in Functional Genomics and Proteomics   Check publisher's open access policy
ISSN 1473-9550
Publication date 2007-12
Year available 2007
Sub-type Article (original research)
DOI 10.1093/bfgp/elm032
Volume 6
Issue 4
Start page 253
End page 264
Total pages 12
Place of publication London
Publisher Henry Stewart
Collection year 2007
Language eng
Subject 060102 Bioinformatics
1107 Immunology
Abstract The immunoglobulin superfamily (IgSF) comprises the immunoglobulins (IG), T cell receptors (TR) and proteins that have the common feature of having at least one Ig-like domain. The major histocompatibility complex (MHC) superfamily (MhcSF) comprises, in addition to the MHC, proteins which share the common feature of having Mhc-like domains. IMGT®, the international ImMunoGeneTics information system® (http://imgt.cines.fr) has set up a unique numbering system and standardized 2D graphical representations, or IMGT Colliers de Perles, which take into account the structural features of the Ig-like and Mhc-like domains. In this article, we review the IMGT Scientific chart rules for the description of the IgSF (V and C types) and of the MhcSF (G type) domains. These rules are based on the IMGT-ONTOLOGY axioms and concepts and are applicable for the sequence and structure analysis, whatever the species, the IgSF or MhcSF protein, or the chain type. These IMGT Colliers de Perles are particularly useful for antibody engineering, sequence–structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis.
Keyword Domain
IMGTCollier de Perles
Immunoglobulin superfamily IgSF
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
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Created: Mon, 19 Jan 2009, 10:17:11 EST by Maryanne Watson on behalf of Institute for Molecular Bioscience