Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference : short report

Sadler, Rudiger, Herzig, Volker and Schmidt, Werner J (2007) Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference : short report. Behavioural Pharmacology, 18 7: 699-703. doi:10.1097/FBP.0b013e3282effb81


Author Sadler, Rudiger
Herzig, Volker
Schmidt, Werner J
Title Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference : short report
Journal name Behavioural Pharmacology   Check publisher's open access policy
ISSN 0955-8810
1473-5849
Publication date 2007-11
Year available 2007
Sub-type Article (original research)
DOI 10.1097/FBP.0b013e3282effb81
Volume 18
Issue 7
Start page 699
End page 703
Total pages 5
Editor Paul Willner
Place of publication London
Publisher Lippincott Williams & Wilkins
Language eng
Subject 060801 Animal Behaviour
Abstract Long-lasting drug-associated memories can contribute to relapse; therefore these memories must be inactivated to enable sustainable success in addiction therapy. As drug associations are usually acquired over several conditioning events, we assume that an effective treatment should be repeatedly applied to achieve persistent effects. In this study, we examine whether 10 repeated memory reactivation tests followed by systemic N-methyl-D-aspartate receptor antagonist MK-801 (0.1 mg/kg) administrations can disrupt memory reconsolidation in rats, leading to a reduction of well-established amphetamine-conditioned place preference (CPP). We found that immediate (but not 60-min delayed) administration of MK-801 after the tests reduced amphetamine-CPP expression after at least four treatments. These effects were specific to CPP expression as no MK-801-induced change in locomotion was observed during all tests. We discuss these results as being caused by MK-801 disrupting memory reconsolidation and we propose the applied repeated-treatment regimen as a new therapeutic research strategy to persistently disrupt drug-associated memories.
Keyword Psychopharmacology
reactivation tests
memory
Reconsolidation
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 15 Jan 2009, 10:45:17 EST by Ms Karen Naughton on behalf of Institute for Molecular Bioscience