MemO: A Consensus Approach to the Annotation of a Protein's Membrane Organization

Davis, Melissa J., Zhang, Fasheng, Yuan, Zheng and Teasdale, Rohan D. (2006) MemO: A Consensus Approach to the Annotation of a Protein's Membrane Organization. In Silico Biology, 6 5: 387-399.

Author Davis, Melissa J.
Zhang, Fasheng
Yuan, Zheng
Teasdale, Rohan D.
Title MemO: A Consensus Approach to the Annotation of a Protein's Membrane Organization
Journal name In Silico Biology   Check publisher's open access policy
ISSN 1386-6338
Publication date 2006
Sub-type Article (original research)
Volume 6
Issue 5
Start page 387
End page 399
Total pages 13
Editor E. Wingender
H. Michael
Place of publication Amsterdam, Netherlands
Publisher IOS Press
Language eng
Abstract Membrane organization describes the relationship of proteins to the membrane, that is, whether the protein crosses the membrane or is integral to the membrane and its orientation with respect to the membrane. Membrane organization is determined primarily by the presence of two features which target proteins to the secretory pathway: the endoplasmic reticulum signal peptide and the α-helical transmembrane domain. In order to generate membrane organization annotation of high quality, confidence and throughput, the Membrane Organization (MemO) pipeline was developed, incorporating consensus feature prediction modules with integration and annotation rules derived from biological observations. The pipeline classifies proteins into six categories based on the presence or absence of predicted features: Soluble, intracellular proteins; Soluble, secreted proteins; Type I membrane proteins; Type II membrane proteins; Multi-span membrane proteins and Glycosylphosphatidylinositol anchored membrane proteins. The MemO pipeline represents an integrated strategy for the application of state-of-the-art bioinformatics tools to the annotation of protein membrane organization, a property which adds biological context to the large quantities of protein sequence information available.
Keyword Integral-membrane protein
Transmembrane domain
Secreted protein
Signal peptide
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
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