Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1

Keating, Damien J., Chen, Chen and Pritchard, Melanie A. (2006) Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1. Ageing research reviews, 5 4: 388-401. doi:10.1016/j.arr.2005.11.001


Author Keating, Damien J.
Chen, Chen
Pritchard, Melanie A.
Title Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1
Journal name Ageing research reviews   Check publisher's open access policy
ISSN 1568-1637
Publication date 2006
Year available 2006
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.arr.2005.11.001
Volume 5
Issue 4
Start page 388
End page 401
Total pages 14
Place of publication Amsterdam
Publisher Elsevier
Collection year 2006
Language eng
Subject 110306 Endocrinology
110201 Cardiology (incl. Cardiovascular Diseases)
111201 Cancer Cell Biology
Abstract Down syndrome (DS) is a genetically-based disorder which results in multiple conditions for sufferers. Amongst these is a common early incidence of Alzheimer's disease (AD) which usually affects DS individuals by their mid 40s. This fact provides a clue that one or more of the genes located on chromosome 21 may be involved in the onset of AD. Current evidence suggests that endosomal disorders may underlie the earliest pathology of AD, preceding the classical pathological markers of β-amyloid plaque deposition and neurofibrillary tangles. Therefore, any genes involved in endocytosis and vesicle trafficking which are over-expressed in DS are novel candidates in the pathogenesis of AD. Intersectin-1 (ITSN1) and Down syndrome candidate region 1 (DSCR1) are two such genes. Extensive in vitro data and data from Drosophila indicates that the over-expression of either of these genes or their products results in inhibition or ablation of endocytosis in neuronal as well as non-neuronal cells. This review discusses in detail the known and potential roles of ITSN1 and DSCR1 in DS, AD, endocytosis and vesicle trafficking.
Keyword Alzheimer's disease
Down Syndrome
Endocytosis
DSCR1
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Q-Index Code C1
Q-Index Status Provisional Code
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Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 28 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 14 Jan 2009, 13:05:42 EST by Marianne Steentsma on behalf of Faculty Of Health Sciences