Arresting angiotensin type 1 receptors

Thomas, Walter G. and Qian, Hongwei (2003) Arresting angiotensin type 1 receptors. Trends in Endocrinology & Metabolism, 14 3: 130-136. doi:10.1016/S1043-2760(03)00023-7

Author Thomas, Walter G.
Qian, Hongwei
Title Arresting angiotensin type 1 receptors
Journal name Trends in Endocrinology & Metabolism   Check publisher's open access policy
ISSN 1043-2760
Publication date 2003-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S1043-2760(03)00023-7
Volume 14
Issue 3
Start page 130
End page 136
Total pages 7
Place of publication New York
Publisher Elsevier Science
Language eng
Subject 270000 Biological Sciences
060110 Receptors and Membrane Biology
060111 Signal Transduction
060199 Biochemistry and Cell Biology not elsewhere classified
060108 Protein Trafficking
060602 Animal Physiology - Cell
110201 Cardiology (incl. Cardiovascular Diseases)
110903 Central Nervous System
Abstract The type 1 angiotensin (AT1) receptor mediates the homeostatic and pathological actions of the peptide hormone, angiotensin II. With regard to the processes that activate and deactivate seven-transmembranespanning, G-protein-coupled receptors (GPCRs), AT1 receptors are among the most widely studied, serving as prototypes for GPCRs that bind and respond to peptide hormones. Arrestins are proteins that bind to activated and phosphorylated GPCRs, terminating initial signals emanating from these receptors, in addition to mediating receptor internalization. New aspects of arrestin function continue to emerge, such as their capacity to act as scaffolds to recruit regulatory and signaling molecules to increase the repertoire of receptor responses. Here, we examine the evidence that arrestins contribute to the signaling, deactivation and trafficking of AT1 receptors.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 30 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 14 Jan 2009, 10:49:39 EST by Ms Julie Anne Hansen on behalf of Library Corporate Services