Angiotensin receptors: form and function and distribution

Thomas, Walter G. and Mendelsohn, Frederick A. O. (2003) Angiotensin receptors: form and function and distribution. International journal of biochemistry & cell biology, 35 6: 774-779. doi:10.1016/S1357-2725(02)00263-7


Author Thomas, Walter G.
Mendelsohn, Frederick A. O.
Title Angiotensin receptors: form and function and distribution
Journal name International journal of biochemistry & cell biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2003-06
Sub-type Article (original research)
DOI 10.1016/S1357-2725(02)00263-7
Volume 35
Issue 6
Start page 774
End page 779
Total pages 6
Place of publication Exeter, England
Publisher Elsevier/Pergamon
Language eng
Subject 270000 Biological Sciences
060110 Receptors and Membrane Biology
060111 Signal Transduction
060199 Biochemistry and Cell Biology not elsewhere classified
060108 Protein Trafficking
060602 Animal Physiology - Cell
110201 Cardiology (incl. Cardiovascular Diseases)
110903 Central Nervous System
Abstract The peptide hormone, angiotensin II, acts primarily via type I (AT1) and type II (AT2) angiotensin receptors. Proteolytic fragments of angiotensin II also have biological activity via these and other receptors, with actions that may mimic or antagonise angiotensin II. Most notably, a high affinity-binding site for angiotensin IV (the Val3-Phe8 fragment of angiotensin II) has recently been identified as the insulin-regulated aminopeptidase (IRAP). While AT1 and AT2 receptors are seven transmembrane-spanning, G protein-coupled receptors with some well-established features of relevance to health and disease, the existence of separate receptor systems for angiotensin fragments offers exciting possibilities for new therapeutics to target the diverse actions of the angiotensin peptides.
Keyword Angiotensin II
Angiotensin IV
AT1
AT2
AT4 receptors
IRAP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biomedical Sciences Publications
 
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